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Identification and Quantitation of Bone Marrow Adipocytes by Immunostaining
Bone marrow adipocytes (BMAds) have been found to impact other cell populations inside the marrow and they can influence the entire body, but the role of adipocytes in bone physiology has been poorly understood. BMAds can ...
Phenotypic impact of keratin 8/18 downregulation in colonic in vitro 3D cultures
The second deadliest and third most common type of cancer is colorectal cancer (CRC). The disease mechanism is to a large extent unknown and the number of cases is on the rise in westernized countries. Interestingly, ...
Development of a T Cell Exhaustion Assay for Identification of Novel Immuno-Oncology Targets and In Vitro Drug Screening
Cancer immunotherapy utilizes the body’s own immune system to treat cancer. The key cell type in immunotherapy is T cells. T cells recognize tumor-associated antigens through their T cell receptors (TCRs) and respond to ...
Karakterisering av Notch1 fosforylering under replikationsstress
Notch1 har en betydande roll i många av cellens funktioner. Tidigare studier visar att Notch deltar i regleringen av ATM/ATR-aktiveringen vid replikationsstress genom att binda till ATM, vilket inhiberar autofosforyleringen ...