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Phenotypic impact of keratin 8/18 downregulation in colonic in vitro 3D cultures
The second deadliest and third most common type of cancer is colorectal cancer (CRC). The disease mechanism is to a large extent unknown and the number of cases is on the rise in westernized countries. Interestingly, ...
Characterization of HSF1 Interactome during Anisomelic Acid Treatment Using TurboID Proximal Labeling
The heat shock response involves the expression of molecular chaperones that aid in re-folding or degradation of proteins in physiological and pathological conditions that promote accumulation of misfolded proteins. A key ...
Zero-Cost Deep Learning to Enhance Microscopy
Combining microscopy image acquisition and deep learning improves image processing and analytics. However, deep learning requires knowledge of information technology and expensive hardware. Also, proper training of the ...
Fosfataset alphabets roll i Drosophila melanogasters immunförsvar
IMD-signalräckan hos bananflugan är en central immunsignaleringsräcka som aktiveras av gramnegativa bakterier. IMD-räckan behövs för att flugan ska inducera och utsöndra NF-κB-beroende antimikrobiella peptider, både vid ...
Modulation of Human Papilloma Virus transcription by Jagged1 in cervical cancer cell lines
The Human Papilloma Virus (HPV) is a common sexually transmitted pathogen and the etiological agent for developing cervical cancer (CC). From the high-risk HPVs (hr-HPV), types 16 and 18 are the most prevalent ones. HPV ...
Developing an in vitro model and quantitation method for bone marrow adiposity research
Bone marrow adipocytes (BMAds) have long been considered a passive and pathological filler within the bone marrow (BM) microenvironment. Recent studies suggest that BMAds may actively influence bone and energy metabolism. ...