Selaus julkaisuajan mukaan kokoelmassa 1182 Biokemia, solu- ja molekyylibiologia
Viitteet 21-40 / 51
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Isolation and functional analysis of phage display-derived scFv-antibodies targeting the S. aureus SSLs
(Åbo Akademi, 2020)Embargo 8/2022. -
Deciphering the molecular composition of tricellular junctions
(Åbo Akademi, 2020)Tight Junctions (TJs) are intercellular adhesion complexes that contain an elaborate network of both transmembrane and cytosolic proteins, regulating epithelium integrity. In this thesis, I studied the interactome of a ... -
Funktionell aktivitet hos inkapslade proteiner i kiseldioxidmikropartiklar
(Åbo Akademi, 2020)Bioterapeutiska proteiner är av intresse då nya läkemedel utvecklas. Eftersom proteiner har en komplex struktur har de viktiga egenskaper såsom hög specifitet, vilket gör att de endast binder till vissa molekyler. Användningen ... -
Karaktärisering av humana NK-celler med specificitet mot immunoterapeutiskt (Fas 1) godkända NK-92-celler
(2021)NK-celler har den unika kapaciteten att döda infekterade eller muterade celler snabbt och effektivt. Dessa egenskaper utnyttjades i denna pro gradu avhandling då cytotoxicitetsanalyser med varierande cytokiner utfördes. ...Embargo until 2022-09-01 -
Fosfataset alphabets roll i Drosophila melanogasters immunförsvar
(2021)IMD-signalräckan hos bananflugan är en central immunsignaleringsräcka som aktiveras av gramnegativa bakterier. IMD-räckan behövs för att flugan ska inducera och utsöndra NF-κB-beroende antimikrobiella peptider, både vid ... -
Modulation of Human Papilloma Virus transcription by Jagged1 in cervical cancer cell lines
(2021)The Human Papilloma Virus (HPV) is a common sexually transmitted pathogen and the etiological agent for developing cervical cancer (CC). From the high-risk HPVs (hr-HPV), types 16 and 18 are the most prevalent ones. HPV ... -
Comparison of in vitro high content screening methods for drug genotoxicity
(2021)Detection of chemicals that induce damage to the DNA is an important aspect in drug development. The recognition of these chemicals is based on in vitro studies followed by in vivo studies, the latter being both expensive ... -
Development of a T Cell Exhaustion Assay for Identification of Novel Immuno-Oncology Targets and In Vitro Drug Screening
(2021)Cancer immunotherapy utilizes the body’s own immune system to treat cancer. The key cell type in immunotherapy is T cells. T cells recognize tumor-associated antigens through their T cell receptors (TCRs) and respond to ...Salassapidettävä 27.5.2025 asti. -
Engineering DoxA activity through the manipulation of associated electron transport partners
(2021)Doxorubicin (DXR) is an anthracycline produced by some strains of the bacterium Streptomyces peucetius subsp. caesius. It is one of the most commonly used drugs in the treatment of several different types of cancer. It is ...Embargo 14/6/2022 asti. -
Autoimmunity-associated polymorphisms and their effects on the immunophenotype : Cohort generation and subject immunophenotyping in the Finnish Diabetes Prediction and Prevention study
(2021)Type 1 diabetes (T1D) has a multifactorial etiology wherein both genetic and environmental factors predispose and modulate an individual’s risk of developing the disease. Hereditary factors are perceived to be the fundamental ... -
Molekylära kopplingar mellan signalförmedlare i olika NF-κB-räckor i epitelceller i Drosophilas tarmkanal
(2021)Bananflugan (Drosophila melanogaster) är en utmärkt modellorganism för att studera cell signaleringsräckor som reglerar aktiveringen av NF-κB-transkriptionsfaktorer. I Drosophila har två NF-κB-immunsignaleringsräckor ... -
Developing an in vitro model and quantitation method for bone marrow adiposity research
(2021)Bone marrow adipocytes (BMAds) have long been considered a passive and pathological filler within the bone marrow (BM) microenvironment. Recent studies suggest that BMAds may actively influence bone and energy metabolism. ...Embargo 26.5.2022 asti -
Karakterisering av Notch1 fosforylering under replikationsstress
(2021)Notch1 har en betydande roll i många av cellens funktioner. Tidigare studier visar att Notch deltar i regleringen av ATM/ATR-aktiveringen vid replikationsstress genom att binda till ATM, vilket inhiberar autofosforyleringen ...Salassapidettävä 6.9.2025 asti. -
dSting reglerar den antivirala NF-ĸB-förmedlade immunresponsen i bananflugan
(2022)Drosophila melanogaster (bananflugan) utgör en utmärkt modellorganism för studier inom immunförsvaret – närmare sagt det ospecifika immunförsvaret, då bananflugan saknar ett specifikt immunförsvar. Bananflugans immunresponser ... -
Identification and Quantitation of Bone Marrow Adipocytes by Immunostaining
(2022)Bone marrow adipocytes (BMAds) have been found to impact other cell populations inside the marrow and they can influence the entire body, but the role of adipocytes in bone physiology has been poorly understood. BMAds can ...Embargo 22.6.2023 asti -
Phenotypic impact of keratin 8/18 downregulation in colonic in vitro 3D cultures
(2022)The second deadliest and third most common type of cancer is colorectal cancer (CRC). The disease mechanism is to a large extent unknown and the number of cases is on the rise in westernized countries. Interestingly, ... -
Ovarian hormones modulating intestinal epithelia – a focus on keratins
(2022)Salassapidettävä 2/6/2024 asti. -
Funktionella och strukturella studier av kollagenbindande α1 och α2 integrin I-domäner
(2022)Integriner är heterodimera proteiner som består av en α-underenhet och en β-underenhet. De medverkar i cell–cell- samt cell-extracellulära matrixinteraktioner och har viktiga roller vid flera olika sjukdomar, såsom cancer, ... -
Towards targeted antibiotics against Lyme disease - Ligand binding properties of Borrelia burgdorferi BmpD
(2022)Salassapidettävä 01/10/2026 asti. -
Evaluating tumour-specificity of mesoporous silica nanoparticle drug delivery in organotypic 3D cultures
(2022)Salassapidettävä 31/10/2026 asti.