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Precision Therapeutics : Harnessing Receptor-targeted and Dynamic DNA Nanotechnology
(Åbo Akademi - Åbo Akademi University, 15.03.2024)In recent years, significant progress has been made in the development of nanomedicines. Nanosystems for targeted drug delivery are a class of nanomaterials capable of delivering drugs to specific cellular locations, ... -
Stimuli-Responsive Prodrug Nanomaterials for Combination Therapy of Cancer
(Åbo Akademi - Åbo Akademi University, 15.12.2023)Cancer is a challenging disease to cure. Current treatment methods mainly include chemotherapy and phototherapy. Chemotherapy drugs, due to their high toxicity and systemic distribution, still cause great suffering for ... -
Tailored Doses by Means of Semi-Solid Extrusion-Based 3D Printing : A Study in Pharmaceutical Sciences
(Åbo Akademi - Åbo Akademi University, 17.11.2023)The field of pharmaceutical sciences recognizes the need for tailored doses to address dosing challenges in specific patient populations, particularly pediatric and veterinary patients. Conventional manufacturing methods ... -
Stimuli-Responsive Porous Nanomaterials for Controlled Drug Delivery and Gene Therapy
(Åbo Akademi - Åbo Akademi University, 25.02.2022)Stimuli-responsive drug delivery systems have become increasingly fascinating and vital in nanomedicine because they can change the drugs pharmacokinetics, significantly improve the drugs utilization efficiency, provide ... -
Printing technologies for personalization of dosage forms
(Åbo Akademi University, 03.12.2021)Along with the recognized advantages of personalized medicine, a demand for new manufacturing technologies that allow for production of such products has emerged. Conventional pharmaceutical manufacturing techniques that ... -
Exploring Printed Drug Formulations for Inkjet and Stencil Printing : A study in Pharmaceutical Sciences
(Åbo Akademi - Åbo Akademi University, 11.12.2020)Solid dosage forms are predominantly produced in large batches of a few and predetermined dose strengths. The current manufacturing methods do not enable high production flexibility and the product quality is assured mainly ... -
Design of Multifunctional Nanoparticles for Cellular Labeling and Tracking, Delivery and Scavenging of Active Substances in vivo
(Åbo Akademi - Åbo Akademi University, 14.05.2019)Nanomedicine, the application of nanotechnology in the biomedical field, has gained tremendous interest for improving diagnostic and therapeutic interventions with potential in personalized medicine. The aim of personalized ... -
Physically and Chemically Modified Cellulose for Drug Delivery
(Åbo Akademi - Åbo Akademi University, 11.05.2018)Modern advances in pharmaceutical industry have raised the interest in designing, modifying and regenerating polymers which can improve the quality of final dosage forms. Cellulose, as the most abundant biopolymer on the ... -
Multimodal imaging probes and delivery systems for cancer nanomedicine
(Åbo Akademi - Åbo Akademi University, 02.03.2018)Nanoparticles have emerged as one of the most promising tools for addressing central challenges in cancer diagnostics and therapy. This thesis presents the design, surface functionalization, biocompatibility, intracellular ... -
Application of analytical techniques in quality control of printed pharmaceutical dosage forms
(Åbo Akademi - Åbo Akademi University, 12.01.2018)There is a need for development and production of pharmaceutical dosage forms with flexible dosing in order to achieve the essential requirements of precision medicine for patient-specific therapy. Precision medicine ... -
Early discovery approaches of biofilm inhibitors from naturally inspired sources and insights into biofilm models
(Åbo Akademi - Åbo Akademi University, 08.12.2017)Biofilm formation complicates diagnosis and treatment of bacterial infections. Bacterial biofilms can be defined as structurally organized communities of bacterial cells embedded in a matrix of extracellular polymeric ... -
Design and development of personalized dosage forms by printing technology
(Åbo Akademi - Åbo Akademi University, 16.06.2017)The development of tailored dosage forms provides a wide range of possibilities for meeting the needs of individual drug therapy. The personalized dosage forms improve the safety of drug treatment by decreasing the risk ... -
Mesoporous silica nanoparticles as versatile intracellular drug delivery platform
(Åbo Akademi - Åbo Akademi University, 25.11.2016)Mesoporous silica nanoparticles (MSNs) have attracted substantial attention for their application in drug delivery and biomedicine. MSNs have been established as a promising and novel drug delivery vehicle due to their ... -
Roles of keratins in intestinal health and disease
(Åbo Akademi - Åbo Akademi University, 27.11.2015)Intermediate filament keratins (K) play a pivotal role in protein targeting and epithelialcytoprotection from stress as evidenced by keratin mutations predisposing to human liver and skin diseases and possibly inflammatory ... -
Biomolecular screening for inhibitors of butyrylcholinesterase : identification and characterization using in vitro and in silico tools
(Åbo Akademi - Åbo Akademi University, 20.11.2013)Drug discovery is a continuous process where researchers are constantly trying to find new and better drugs for the treatment of various conditions. Alzheimer’s disease, a neurodegenerative disease mostly affecting the ... -
A platform for anti-biofilm assays combining viability, biomass and matrix quantifications in susceptibility assessments of antimicrobials against Staphylococcus aureus biofilms
(Åbo Akademi - Åbo Akademi University, 09.11.2012)Bacteria can exist as planktonic, the lifestyle in which single cells exist in suspension, and as biofilms, which are surface-attached bacterial communities embedded in a selfproduced matrix. Most of the antibiotics and ... -
Development of simple and efficient synthetic strategies for production of fine chemicals of pharmaceutical relevance : metal-mediated allylation combined with applied catalysis
(Åbo Akademi - Åbo Akademi University, 25.05.2012)
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