Selaus asiasanan mukaan kokoelmassa 1182 Biokemia, solu- ja molekyylibiologia
Viitteet 1-20 / 27
-
Assessment of endocrine disrupting activities in the aquatic environment
(Åbo Akademi - Åbo Akademi University, 16.01.2009)Hormonstörande ämnen är syntetiska eller naturliga ämnen som stör organismers hormonsystem och bidrar till könsförvirring och sterilitet. Sådana ämnen kommer i ökande takt ut i vattenmiljön genom rester av läkemedel, ... -
Cellular responses to stress and kinase signaling activation : apoptosis and differentiation
(Åbo Akademi - Åbo Akademi University, 13.08.2013)Stress signals are often sensed by membrane-bound proteins which translate signals into the chemical modification of molecules, most notably protein kinases. These kinases, in turn, transmit the decoded message through a ... -
Choosing the target loci : heat shock factors HSF1 and HSF2 as regulators of cell stress and development
(Åbo Akademi - Åbo Akademi University, 29.08.2014)Heat shock factors (HSFs) are an evolutionarily well conserved family of transcription factors that coordinate stress-induced gene expression and direct versatile physiological processes in eukaryote organisms. The ... -
Dynamic interplay between the intermediate filament protein nestin and Cyclin-dependent kinase 5
(Åbo Akademi - Åbo Akademi University, 29.10.2010) -
JNK, a versatile regulator of kinesin-1 transport and cytoskeleton dynamics
(Åbo Akademi - Åbo Akademi University, 11.02.2013)C-Jun N-terminal kinase (JNK) is traditionally recognized as a crucial factor in stress response and inducer of apoptosis upon various stimulations. Three isoforms build the JNK subfamily of MAPK; generally expressed JNK1 ... -
Keratiner i den endokrina bukspottkörteln : Nya regulatorer av cellulära processer i β-celler
(Åbo Akademi - Åbo Akademi University, 09.02.2018) -
Kinase function in Parkinson’s disease and neuronal transport
(Åbo Akademi - Åbo Akademi University, 03.11.2017) -
Models to study intermediate filament dynamics and functions
(Åbo Akademi - Åbo Akademi University, 08.01.2016)Intermediate filaments are part of the cytoskeleton and nucleoskeleton; they provide cells with structure and have important roles in cell signalling. The IFs are a large protein family with more than 70 members; each ... -
Nanoclustering augmentation : a novel mechanism of Ras activation in cancer
(Åbo Akademi - Åbo Akademi University, 12.02.2016)Proteins of the Ras family are central regulators of crucial cellular processes, such as proliferation, differentiation and apoptosis. Their importance is emphasized in cancer, in which the isoforms H-ras, N-ras and K-ras ... -
Networking Notch : regulation of Notch traffic and signaling crosstalk
(Åbo Akademi - Åbo Akademi University, 13.10.2015)- -
Novel cancer-related regulatory targets for the signalling sphingolipids sphingosine-1-phosphate and sphingosylphosphorylcholine
(Åbo Akademi - Åbo Akademi University, 29.04.2016)The signalling sphingolipid sphingosine-1-phosphate (S1P) is necessary for development of the immune system and vasculature and on a cellular level regulates migration, proliferation and survival. Due to these traits S1P ... -
On the Evolution, Function and Pathogenesis of Intermediate Filaments
(Åbo Akademi - Åbo Akademi University, 02.06.2017)Intermediärfilament (IF) är nukleära och cytoplasmiska strukturprotein. I människans genom ingår 70 gener som kodar för 74 hittills kända intermediärfilament. Mutationer i dessa gener orsakar många allvarliga sjukdomar. ... -
Regulation of cell fate by c-FLIP phosphorylation
(Åbo Akademi - Åbo Akademi University, 13.12.2013)Programmed cell death is an important physiological cellular process that maintains homeostasis and protects multicellular organisms from diseases. Apoptosis is the principal mode of cell death, which eliminates unwanted ... -
Regulation of HSF2 and its function in mitosis
(Åbo Akademi - Åbo Akademi University, 26.09.2014)The cell is continuously subjected to various forms of external and intrinsic proteindamaging stresses, including hyperthermia, pathophysiological states, as well as cell differentiation and proliferation. Proteindamaging ... -
Role and regulatory mechanisms of heat shock factor 2
(Åbo Akademi - Åbo Akademi University, 04.11.2011)Protein homeostasis is essential for cells to prosper and survive. Various forms of stress, such as elevated temperatures, oxidative stress, heavy metals or bacterial infections cause protein damage, which might lead to ... -
Role of the canonical transient receptor potential channel 2 (TRPC2) in thyroid cell function
(Åbo Akademi - Åbo Akademi University, 08.02.2013)- -
Sphingosine 1-phosphate receptor 2 and the trpc1 ion channel as regulators of human thyroid cancer cell migration and proliferation
(Åbo Akademi - Åbo Akademi University, 22.09.2017)Thyroid cancer is the most common endocrine cancer and currently there is no effective treatment available against the most aggressive and highly invasive forms of thyroid cancer. Sphingosine 1-phosphate (S1P) is a bioactive ... -
Sphingosine-1-phosphate-evoked invasion of follicular thyroid cancer cells : evidence for the involvement of HIF-I?, MMP2 and MMP9
(Åbo Akademi - Åbo Akademi University, 11.09.2015)Sphingolipids are widely expressed molecules, which traditionally were considered to have majorly structural properties. Nowadays, however, they are implicated in a wide range of different biological processes. The bioactive ... -
Stress management : multilayer regulation of the heat shock response
(Åbo Akademi - Åbo Akademi University, 21.04.2017)Protein-damaging stresses, such as exposure to elevated temperature, alcohol, and heavy metals and microbial infections, increase the amount of misfolded proteins in cells, which may lead to formation of toxic protein ... -
Structural studies and in vivo characterisation of Oct4:PORE and Oct4/Sox2:UTF1 complexes
(Åbo Akademi - Åbo Akademi University, 03.06.2014)-