Selaus syöttöajan mukaan kokoelmassa 1182 Biokemia, solu- ja molekyylibiologia
Viitteet 1-20 / 63
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Met1-ubiquitination determines inflammatory signalling in Drosophila melanogaster
(Åbo Akademi - Åbo Akademi University, 15.06.2022)The innate immune response is an immediate immune response facilitated by the host to combat pathogen invasion and other harmful stimuli, such as damaged cells and environmental irritants. It is activated when pattern-recognising ... -
Mechanisms of Nascent Transcription in Cell Stress
(Åbo Akademi - Åbo Akademi University, 13.05.2022)Cells are constantly exposed to various types of stress, such as proteotoxic stress, oxidative stress, and hypoxia. Survival under these circumstances requires genome-wide reprogramming of transcription involving both ... -
Regulation of Host-Microbe Interactions and Inflammatory Signalling in Drosophila melanogaster
(Åbo Akademi University, 10.12.2021)In order to eliminate harmful pathogens, while allowing beneficial microbes to persist, inflammatory signalling in the intestine needs to be carefully regulated. Overactive immune signalling can lead to chronic inflammation ... -
The Dynamic Structural Effects of Activating ERBB Kinase Somatic Mutations
(Åbo Akademi University, 15.10.2021)The ERBB family of receptor tyrosine kinases, epidermal growth factor receptor (EGFR, ERBB1), ERBB2, ERBB3 and ERBB4, are transmembrane signaling proteins that regulate cellular processes such as cell survival, mobility, ... -
Vimentin links hemodynamic forces and Notch signaling in vascular tissue remodeling
(Åbo Akademi University, 09.07.2021) -
Virulence and survival mechanisms in Borrelia and Klebsiella infections – a structural bioinformatics perspective
(Åbo Akademi University, 23.06.2021)Bacteria use a wide variety of mechanisms to establish an infection in their host and to compete with other microorganisms for space and nutrients. These virulence and survival mechanisms mainly rely on the functions of ... -
Molecular Basis of the Sticholysin-Membrane Interaction : On the Structure of the Pore and the Effects of Lipids
(Åbo Akademi University Universidad Complutense de Madrid, 18.06.2021)The usefulness of toxicity across the tree of life is far beyond doubt. Most, if not all, organisms produce compounds that can be used for attack and/or defense against external entities. Some of the most specialized of ... -
Membrane lipid frustration : Contribution of ceramide and its effects on lateral segregation
(Åbo Akademi University, 17.06.2021)Ceramides are both sphingolipid precursor molecules and breakdown products with effects on membranes that are of interest both from biophysical and physiological points of view. When present in a membrane, ceramide induces ... -
Development of Novel Drugs Targeting Chaperones of Oncogenic K-Ras
(Åbo Akademi - Åbo Akademi University, 12.02.2021)KRAS mutations account globally for about one million deaths per year, but there is as yet no approved drug against KRAS. K-Ras proteins are organized into di-/oligomeric nanoscale signaling complexes, known as nanoclusters ... -
Cellular regulation of the Notch signaling pathway by Notch-interacting proteins
(Åbo Akademi University, 25.09.2020)The Notch signaling mechanism is a crucial regulator of stem cells during development and tissue regeneration. Transcriptional activation of Notch target genes requires cleavage of the Notch receptor in response to ligand ... -
Identification of Three Conserved Interaction Zones Around the Catalytic Machinery of alpha/beta- Hydrolase Fold Enzymes
(Åbo Akademi - Åbo Akademi University, 06.03.2020)The alpha/beta-Hydrolases (ABH) comprise one of the largest structural families of proteins, found in all organisms. Although they share low sequence similarity, the ABH fold enzymes maintain a common catalytic domain, the ... -
Regulation of Notch Signaling by Intracellular Trafficking
(Åbo Akademi - Åbo Akademi University, 21.02.2020)The Notch signaling pathway is one of the essential mediators of cell-cell communication during development of multicellular organisms. Notch signaling is based on receptors and ligands that interact between neighboring ... -
Nanoparticles as Targeting System for Cancer Treatment : From idea towards reality
(Åbo Akademi - Åbo Akademi University, 20.09.2019)To be able to target cells of interest is one of the key aims in medicine today, because it could minimize side effects of drugs. This is of special importance in cancer therapies, were the treatment has serious side-effects ... -
Bioinformatics Characterization of Amine Oxidases
(Åbo Akademi - Åbo Akademi University, 14.12.2018)Amine oxidases catalyse the oxidative degradation of amines into the corresponding aldehyde, ammonia and hydrogen peroxide. They can be classified into different subfamilies based on the prosthetic group: (1) proteins with ... -
Structural characterization of avidins with novel binding properties
(Åbo Akademi - Åbo Akademi University, 14.09.2018)Avidin (Avd) is a protein first discovered in chicken egg white, and later in other birds, reptiles, amphibians and lancelet. Apart from these eukaryoticspecies, Avd is also identified in few fungal and in many bacterial ... -
The role of keratins in proliferation, differentiation and hypoxia signaling in colonic epithelia
(Åbo Akademi - Åbo Akademi University, 17.08.2018)Keratin (K) intermediate filament proteins are important in stress protection and in providing mechanical support to colonic epithelial cells. Deletion of K8 in mice (K8-/-) leads to colonic epithelial hyperproliferation, ... -
The regulatory role of butyrolactone I in the filamentous fungus Aspergillus terreus
(Åbo Akademi - Åbo Akademi University, 08.06.2018)An industrially and pharmaceutically important filamentous fungus, Aspergillus terreus, is known to biosynthesise plentiful natural products including lovastatin, a serum cholesterol lowering agent. A. terreus has also ... -
Impact of lipid-lipid interactions on lateral segregation in bilayers
(Åbo Akademi - Åbo Akademi University, 18.05.2018)The vast diversity of lipid species found in cells suggests that structural variation of lipids is essential for the normal function of the cell. One essential reason could be the formation of lateral heterogeneity in cell ... -
Regulation of cellular stress proteins in physiology and disease
(Åbo Akademi - Åbo Akademi University, 18.05.2018)All cells in a human body are constantly exposed to environmental fluctuations to which the cells must respond. Most of the cellular responses are mediated by proteins that are specifically regulated according to the ... -
Keratiner i den endokrina bukspottkörteln : Nya regulatorer av cellulära processer i β-celler
(Åbo Akademi - Åbo Akademi University, 09.02.2018)