Selaus syöttöajan mukaan kokoelmasssa 1182 Biokemia, solu- ja molekyylibiologia
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Identification of Three Conserved Interaction Zones Around the Catalytic Machinery of alpha/beta- Hydrolase Fold Enzymes
(Åbo Akademi - Åbo Akademi University, 06.03.2020)The alpha/beta-Hydrolases (ABH) comprise one of the largest structural families of proteins, found in all organisms. Although they share low sequence similarity, the ABH fold enzymes maintain a common catalytic domain, the ... -
Regulation of Notch Signaling by Intracellular Trafficking
(Åbo Akademi - Åbo Akademi University, 21.02.2020)The Notch signaling pathway is one of the essential mediators of cell-cell communication during development of multicellular organisms. Notch signaling is based on receptors and ligands that interact between neighboring ... -
Nanoparticles as Targeting System for Cancer Treatment : From idea towards reality
(Åbo Akademi University, 20.09.2019)To be able to target cells of interest is one of the key aims in medicine today, because it could minimize side effects of drugs. This is of special importance in cancer therapies, were the treatment has serious side-effects ... -
Novel tools to investigate and control JNK function in models of anxiety and depression
(Åbo Akademi University, 13.02.2019) -
Bioinformatics Characterization of Amine Oxidases
(Åbo Akademi University, 14.12.2018)Amine oxidases catalyse the oxidative degradation of amines into the corresponding aldehyde, ammonia and hydrogen peroxide. They can be classified into different subfamilies based on the prosthetic group: (1) proteins with ... -
Structural characterization of avidins with novel binding properties
(Åbo Akademi University, 14.09.2018)Avidin (Avd) is a protein first discovered in chicken egg white, and later in other birds, reptiles, amphibians and lancelet. Apart from these eukaryoticspecies, Avd is also identified in few fungal and in many bacterial ... -
The role of keratins in proliferation, differentiation and hypoxia signaling in colonic epithelia
(Åbo Akademi University, 17.08.2018)Keratin (K) intermediate filament proteins are important in stress protection and in providing mechanical support to colonic epithelial cells. Deletion of K8 in mice (K8-/-) leads to colonic epithelial hyperproliferation, ... -
The regulatory role of butyrolactone I in the filamentous fungus Aspergillus terreus
(Åbo Akademi University, 08.06.2018)An industrially and pharmaceutically important filamentous fungus, Aspergillus terreus, is known to biosynthesise plentiful natural products including lovastatin, a serum cholesterol lowering agent. A. terreus has also ... -
Impact of lipid-lipid interactions on lateral segregation in bilayers
(Åbo Akademi University, 18.05.2018)The vast diversity of lipid species found in cells suggests that structural variation of lipids is essential for the normal function of the cell. One essential reason could be the formation of lateral heterogeneity in cell ... -
Regulation of cellular stress proteins in physiology and disease
(Åbo Akademi University, 18.05.2018)All cells in a human body are constantly exposed to environmental fluctuations to which the cells must respond. Most of the cellular responses are mediated by proteins that are specifically regulated according to the ... -
Keratiner i den endokrina bukspottkörteln : Nya regulatorer av cellulära processer i β-celler
(Åbo Akademi University, 09.02.2018) -
Studies on Ceramide/Colipid Interactions in Complex Bilayers
(Åbo Akademi University, 01.12.2017)Ceramide belongs to an important class of sphingolipids and it constitutes the hydrophobic backbone of all complex sphingolipids. Ceramide plays an important role in different biological processes such as cell signaling, ... -
Kinase function in Parkinson’s disease and neuronal transport
(Åbo Akademi university, 03.11.2017) -
Sphingosine 1-phosphate receptor 2 and the trpc1 ion channel as regulators of human thyroid cancer cell migration and proliferation
(Åbo Akademi University, 22.09.2017)Thyroid cancer is the most common endocrine cancer and currently there is no effective treatment available against the most aggressive and highly invasive forms of thyroid cancer. Sphingosine 1-phosphate (S1P) is a bioactive ... -
On the evolution, function and pathogenesis of intermediate filaments
(Åbo Akademi University, 02.06.2017)- -
Stress management : multilayer regulation of the heat shock response
(Åbo Akademi University, 21.04.2017)Protein-damaging stresses, such as exposure to elevated temperature, alcohol, and heavy metals and microbial infections, increase the amount of misfolded proteins in cells, which may lead to formation of toxic protein ... -
Structure in stress management : Keratins in intestinal stress protection
(Åbo Akademi University, 16.12.2016)Intermediate filaments (IFs), a major constituent of the cellular cytoskeleton, contribute mainly to the mechanical stability of the cell. Simple epithelial keratins (SEKs) are IF proteins expressed in the single-layered ... -
Phosphorylation as a mediator of protein function in cell migration, differentiation, and death : vimentin, AATF, and Par-4 in the spotlight
(Åbo Akademi University, 11.11.2016)Protein phosphorylation is a major regulator of cellular signaling. It functions when a kinase joins a phosphate group to a protein, or when a phosphatase strips off a phosphate group from serine, threonine, or tyrosine ... -
Integrin evolution : from prokaryotes to the diversification within chordates
(Åbo Akademi University, 14.10.2016)Integrins are a family of large multi-domain cell surface receptors responsible for bidirectional signaling in response to cell-cell, cell-extracellular matrix interactions as well as intracellular interactions. Intrgrins ... -
Moving lipids : ceramides, glycosphingolipids and the glycolipid transfer protein
(Åbo Akademi University, 20.05.2016)Lipid movement in cells occurs by a variety of methods. Lipids diffuse freely along the lateral plane of a membrane and can translocate between the lipid leaflets, either spontaneously or with the help of enzymes. Lipid ...
