Selaus tekijän mukaan kokoelmassa 1182 Biokemia, solu- ja molekyylibiologia
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Biogeochemistry in acid sulphate soil landscapes and small urban centres in Western Finland
Fältmarsch, Rasmus (Åbo Akademi - Åbo Akademi University, 29.01.2010)The overall purpose of this thesis was to increase the knowledge on the biogeochemistry of rural acid sulphate (AS) soil environments and urban forest ecosystems near small towns in Western Finland. In addition, the potential ... -
Cellular responses to stress and kinase signaling activation : apoptosis and differentiation
Ferraris, Saima (Åbo Akademi - Åbo Akademi University, 13.08.2013)Stress signals are often sensed by membrane-bound proteins which translate signals into the chemical modification of molecules, most notably protein kinases. These kinases, in turn, transmit the decoded message through a ... -
Choosing the target loci : heat shock factors HSF1 and HSF2 as regulators of cell stress and development
Vihervaara, Anniina (Åbo Akademi - Åbo Akademi University, 29.08.2014)Heat shock factors (HSFs) are an evolutionarily well conserved family of transcription factors that coordinate stress-induced gene expression and direct versatile physiological processes in eukaryote organisms. The ... -
Contributions to risk assessment of microcystins, cyanobacterial toxins : development of immunoanalysis and characterization of microcystin variants
Vesterkvist, Pia (Åbo Akademi - Åbo Akademi University, 15.06.2012) -
Dynamic interplay between the intermediate filament protein nestin and Cyclin-dependent kinase 5
Pallari, Hanna (Åbo Akademi - Åbo Akademi University, 29.10.2010) -
Effects of methylation and hydroxylation of sphingomyelins on their biophysical properties and interactions with cholesterol
Jaikishan, Shishir (Åbo Akademi - Åbo Akademi University, 28.09.2012) -
Fast LC-MS detection of cyanobacteria peptide hepatotoxins – method development for determination of total contamination levels in biological materials
Neffling, Milla-Riina (Åbo Akademi - Åbo Akademi University, 05.11.2010) -
Glycolipid and ceramide transfer proteins : important determinants for their function
Tuuf, Jessica (Åbo Akademi - Åbo Akademi University, 12.04.2013)- -
JNK, a versatile regulator of kinesin-1 transport and cytoskeleton dynamics
Padzik, Artur (Åbo Akademi - Åbo Akademi University, 11.02.2013)C-Jun N-terminal kinase (JNK) is traditionally recognized as a crucial factor in stress response and inducer of apoptosis upon various stimulations. Three isoforms build the JNK subfamily of MAPK; generally expressed JNK1 ... -
Lethal weapons : novel approaches for receptor-targeted cancer cell elimination
Peuhu, Emilia (Åbo Akademi - Åbo Akademi University, 17.12.2010)The currently used forms of cancer therapy are associated with drug resistance and toxicity to healthy tissues. Thus, more efficient methods are needed for cancer-specific induction of growth arrest and programmed cell ... -
Membrane properties of structurally modified ceramides : effects on lipid lateral distribution and sphingomyelin-interactions in artificial bilayer membranes
Maula, Terhi (Åbo Akademi - Åbo Akademi University, 14.03.2014)Ceramides comprise a class of sphingolipids that exist only in small amounts in cellular membranes, but which have been associated with important roles in cellular signaling processes. The influences that ceramides have ... -
Muscarinic toxins : characterization of adrenoceptor binding and applicability of membrane anchoring via glycosylphosphatidylinositol tail
Näreoja, Katja (Åbo Akademi - Åbo Akademi University, 31.01.2014)Adrenoceptors (ARs), G-protein coupled receptors (GPCRs) at the plasma membrane, respond to endogenous catecholamines noradrenaline and adrenaline. These receptors mediate several important physiological functions being ... -
Prediction of 3D structure and ligand-binding properties : ABC transporters and flavodiiron proteins from Synechocystis sp. strain PCC 6803
Brandt, Anna-Maria (Åbo Akademi - Åbo Akademi University, 24.05.2013)Cyanobacteria are unicellular, non-nitrogen-fixing prokaryotes, which perform photosynthesis similarly as higher plants. The cyanobacterium Synechocystis sp. strain PCC 6803 is used as a model organism in photosynthesis ... -
Regulation of cell fate by c-FLIP phosphorylation
Asaoka, Tomoko (Åbo Akademi - Åbo Akademi University, 13.12.2013)Programmed cell death is an important physiological cellular process that maintains homeostasis and protects multicellular organisms from diseases. Apoptosis is the principal mode of cell death, which eliminates unwanted ... -
Regulation of HSF2 and its function in mitosis
Elsing, Alexandra (Åbo Akademi - Åbo Akademi University, 26.09.2014)The cell is continuously subjected to various forms of external and intrinsic proteindamaging stresses, including hyperthermia, pathophysiological states, as well as cell differentiation and proliferation. Proteindamaging ... -
Removal of cyanobacterial toxins by strains of probiotic bacteria
Nybom, Sonja (Åbo Akademi - Åbo Akademi University, 21.12.2011) -
Role and regulatory mechanisms of heat shock factor 2
Björk, Johanna (Åbo Akademi - Åbo Akademi University, 04.11.2011)Protein homeostasis is essential for cells to prosper and survive. Various forms of stress, such as elevated temperatures, oxidative stress, heavy metals or bacterial infections cause protein damage, which might lead to ... -
Role of the canonical transient receptor potential channel 2 (TRPC2) in thyroid cell function
Sukumaran, Pramod (Åbo Akademi - Åbo Akademi University, 08.02.2013)- -
Selective inhibition of human tankyrases
Narwal, Mohit (Åbo Akademi - Åbo Akademi University, 28.03.2014)Tankyrases belong to the Diphtheria toxin-like ADP-ribosyltransferase (ARTD) enzyme superfamily, also known as poly(ADP-ribose) polymerases (PARPs). They catalyze a covalent post-translational modification reaction where ... -
Studies on membrane properties of cholesterol and 3-beta modified sterol analogs
Lönnfors, Max (Åbo Akademi - Åbo Akademi University, 28.11.2014)Cholesterol (Chol) is an important lipid in cellular membranes functioning both as a membrane fluidity regulator, permeability regulator and co-factor for some membrane proteins, e.g. G-protein coupled receptors. It also ...