Selaus julkaisuajan mukaan kokoelmassa 1182 Biokemia, solu- ja molekyylibiologia
Viitteet 21-40 / 73
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Tuning cell motility : roles of nestin and vimentin in cancer cell invasion and motility
(Åbo Akademi - Åbo Akademi University, 16.05.2014)The cytoskeleton is a key feature of both prokaryotic and eukaryotic cells. Itis comprised of three protein families, one of which is the intermediate filaments (IFs). Of these, the IFs are the largest and most diverse. ... -
Structural studies and in vivo characterisation of Oct4:PORE and Oct4/Sox2:UTF1 complexes
(Åbo Akademi - Åbo Akademi University, 03.06.2014)- -
Choosing the target loci : heat shock factors HSF1 and HSF2 as regulators of cell stress and development
(Åbo Akademi - Åbo Akademi University, 29.08.2014)Heat shock factors (HSFs) are an evolutionarily well conserved family of transcription factors that coordinate stress-induced gene expression and direct versatile physiological processes in eukaryote organisms. The ... -
Regulation of HSF2 and its function in mitosis
(Åbo Akademi - Åbo Akademi University, 26.09.2014)The cell is continuously subjected to various forms of external and intrinsic proteindamaging stresses, including hyperthermia, pathophysiological states, as well as cell differentiation and proliferation. Proteindamaging ... -
Studies on membrane properties of cholesterol and 3-beta modified sterol analogs
(Åbo Akademi - Åbo Akademi University, 28.11.2014)Cholesterol (Chol) is an important lipid in cellular membranes functioning both as a membrane fluidity regulator, permeability regulator and co-factor for some membrane proteins, e.g. G-protein coupled receptors. It also ... -
To divide or differentiate? : nestin-mediated regulation of Cdk5 in cell fate decisions
(Åbo Akademi - Åbo Akademi University, 30.06.2015)The molecular functions of the non-cell cycle-related Cyclin-dependent kinase 5 (Cdk5) have been of primary interest within the neuroscience field, but novel undertakings are constantly emerging for the kinase in tissue ... -
Sphingosine-1-phosphate-evoked invasion of follicular thyroid cancer cells : evidence for the involvement of HIF-I?, MMP2 and MMP9
(Åbo Akademi - Åbo Akademi University, 11.09.2015)Sphingolipids are widely expressed molecules, which traditionally were considered to have majorly structural properties. Nowadays, however, they are implicated in a wide range of different biological processes. The bioactive ... -
Networking Notch : regulation of Notch traffic and signaling crosstalk
(Åbo Akademi - Åbo Akademi University, 13.10.2015)- -
From protein structure to function with bioinformatics
(Åbo Akademi - Åbo Akademi University, 27.11.2015)It has long been known that amino acids are the building blocks for proteins and govern their folding into specific three-dimensional structures. However, the details of this process are still unknown and represent one of ... -
VAP-1 as drug target in inflammation : structural features determining ligand interactions
(Åbo Akademi - Åbo Akademi University, 05.12.2015)Vascular adhesion protein-1 (VAP-1), which belongs to the copper amine oxidases (CAOs), is a validated drug target in inflammatory diseases. Inhibition of VAP-1 blocks the leukocyte trafficking to sites of inflammation and ... -
Models to study intermediate filament dynamics and functions
(Åbo Akademi - Åbo Akademi University, 08.01.2016)Intermediate filaments are part of the cytoskeleton and nucleoskeleton; they provide cells with structure and have important roles in cell signalling. The IFs are a large protein family with more than 70 members; each ... -
Targeting oncogenic signaling proteins : new insights using a FRET-based chemical biology approach
(Åbo Akademi - Åbo Akademi University, 15.01.2016)Cancer affects more than 20 million people each year and this rate is increasing globally. The Ras/MAPK-pathway is one of the best-studied cancer signaling pathways. Ras proteins are mutated in almost 20% of all human ... -
Nanoclustering augmentation : a novel mechanism of Ras activation in cancer
(Åbo Akademi - Åbo Akademi University, 12.02.2016)Proteins of the Ras family are central regulators of crucial cellular processes, such as proliferation, differentiation and apoptosis. Their importance is emphasized in cancer, in which the isoforms H-ras, N-ras and K-ras ... -
The role of keratin intermediate filaments in the colon epithelial cells
(Åbo Akademi - Åbo Akademi University, 18.02.2016)Keratins (K) are cytoskeletal proteins mainly expressed in the epithelium and constitute the largest subgroup of intermediate filaments (IFs). Simple epithelial keratins (SEKs) K7-K8 and K18-K20 are the major IF elements ... -
Novel cancer-related regulatory targets for the signalling sphingolipids sphingosine-1-phosphate and sphingosylphosphorylcholine
(Åbo Akademi - Åbo Akademi University, 29.04.2016)The signalling sphingolipid sphingosine-1-phosphate (S1P) is necessary for development of the immune system and vasculature and on a cellular level regulates migration, proliferation and survival. Due to these traits S1P ... -
Moving lipids : ceramides, glycosphingolipids and the glycolipid transfer protein
(Åbo Akademi - Åbo Akademi University, 20.05.2016)Lipid movement in cells occurs by a variety of methods. Lipids diffuse freely along the lateral plane of a membrane and can translocate between the lipid leaflets, either spontaneously or with the help of enzymes. Lipid ... -
Integrin evolution : from prokaryotes to the diversification within chordates
(Åbo Akademi - Åbo Akademi University, 14.10.2016)Integrins are a family of large multi-domain cell surface receptors responsible for bidirectional signaling in response to cell-cell, cell-extracellular matrix interactions as well as intracellular interactions. Intrgrins ... -
Phosphorylation as a mediator of protein function in cell migration, differentiation, and death : vimentin, AATF, and Par-4 in the spotlight
(Åbo Akademi - Åbo Akademi University, 11.11.2016)Protein phosphorylation is a major regulator of cellular signaling. It functions when a kinase joins a phosphate group to a protein, or when a phosphatase strips off a phosphate group from serine, threonine, or tyrosine ... -
Structure in stress management : Keratins in intestinal stress protection
(Åbo Akademi - Åbo Akademi University, 16.12.2016)Intermediate filaments (IFs), a major constituent of the cellular cytoskeleton, contribute mainly to the mechanical stability of the cell. Simple epithelial keratins (SEKs) are IF proteins expressed in the single-layered ... -
Stress management : multilayer regulation of the heat shock response
(Åbo Akademi - Åbo Akademi University, 21.04.2017)Protein-damaging stresses, such as exposure to elevated temperature, alcohol, and heavy metals and microbial infections, increase the amount of misfolded proteins in cells, which may lead to formation of toxic protein ...