Haku
Viitteet 1-10 / 13
The Role of Vimentin in Tissue Repair and Cell Growth
(Åbo Akademi - Åbo Akademi University, 2023-03-10)
Microfilaments, microtubules, and intermediate filaments serve as the cytoskeleton of the cell and form a complex network by interacting with cytoskeleton-associated proteins. The cytoskeleton provides a framework for the ...
HSF1 and HSF2 in Stress and EMT-Associated Transcriptional Networks
(Åbo Akademi - Åbo Akademi University, 2023-09-15)
Protein-damaging stress frequently occurs during the lifetime of a cell. To survive these insults, cells rely on the action of proteins called transcription factors that adjust the expression of genes, such as chaperones, ...
Calcium Signaling in Cell Compartments - the Importance of Sphingosine Kinase 1 and ORP5/8
(Åbo Akademi - Åbo Akademi University, 2023-06-21)
För att upprätthålla liv använder cellerna i en organism intrikata signaleringsräckor för regleringen av fysiologiska processer inom enskilda celler och mellan olika celler och vävnaderna som utgör en organism. Reglering ...
Intertwining Cell Adhesion, Gene Expression, and Stress
(Åbo Akademi - Åbo Akademi University, 2023-06-01)
Cells within an organism are constantly exposed to environmental insults that challenge the homeostasis of their proteome by causing protein misfolding. To survive these adverse situations, cells are equipped with a ...
Development of Novel Drugs Targeting Chaperones of Oncogenic K-Ras
(Åbo Akademi - Åbo Akademi University, 2021-02-12)
KRAS mutations account globally for about one million deaths per year, but there is as yet no approved drug against KRAS. K-Ras proteins are organized into di-/oligomeric nanoscale signaling complexes, known as nanoclusters ...
Vimentin links hemodynamic forces and Notch signaling in vascular tissue remodeling
(Åbo Akademi University, 2021-07-09)
Mechanisms of Nascent Transcription in Cell Stress
(Åbo Akademi - Åbo Akademi University, 2022-05-13)
Cells are constantly exposed to various types of stress, such as proteotoxic stress, oxidative stress, and hypoxia. Survival under these circumstances requires genome-wide reprogramming of transcription involving both ...
Regulation of Host-Microbe Interactions and Inflammatory Signalling in Drosophila melanogaster
(Åbo Akademi University, 2021-12-10)
In order to eliminate harmful pathogens, while allowing beneficial microbes to persist, inflammatory signalling in the intestine needs to be carefully regulated. Overactive immune signalling can lead to chronic inflammation ...
Spatial control of angiogenesis by engineered patterns of Notch ligands
(Åbo Akademi - Åbo Akademi University, 2022-10-04)
Spatial control of angiogenesis by engineered patterns of Notch
In tissue engineering and regenerative medicine, proper vascularization of engineered tissues is imperative, as diffusion of nutrients, oxygen and waste is ...
The Role of Exosomal Vimentin in Mediating Wound Healing
(Åbo Akademi - Åbo Akademi University, 2022-11-16)
Despite great advances in tissue engineering and regenerative medicine,impaired wound healing is still a challenging clinical problem. Accumulating evidence demonstrates the ability of extracellular vesicles and specifically, ...