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Studies on Ceramide/Colipid Interactions in Complex Bilayers
(Åbo Akademi - Åbo Akademi University, 2017-12-01)
Ceramide belongs to an important class of sphingolipids and it constitutes the hydrophobic backbone of all complex sphingolipids. Ceramide plays an important role in different biological processes such as cell signaling, ...
Integrin evolution : from prokaryotes to the diversification within chordates
(Åbo Akademi - Åbo Akademi University, 2016-10-14)
Integrins are a family of large multi-domain cell surface receptors responsible for bidirectional signaling in response to cell-cell, cell-extracellular matrix interactions as well as intracellular interactions. Intrgrins ...
Sphingosine 1-phosphate receptor 2 and the trpc1 ion channel as regulators of human thyroid cancer cell migration and proliferation
(Åbo Akademi - Åbo Akademi University, 2017-09-22)
Thyroid cancer is the most common endocrine cancer and currently there is no effective treatment available against the most aggressive and highly invasive forms of thyroid cancer. Sphingosine 1-phosphate (S1P) is a bioactive ...
Fast LC-MS detection of cyanobacteria peptide hepatotoxins – method development for determination of total contamination levels in biological materials
(Åbo Akademi - Åbo Akademi University, 2010-11-05)
Muscarinic toxins : characterization of adrenoceptor binding and applicability of membrane anchoring via glycosylphosphatidylinositol tail
(Åbo Akademi - Åbo Akademi University, 2014-01-31)
Adrenoceptors (ARs), G-protein coupled receptors (GPCRs) at the plasma membrane, respond to endogenous catecholamines noradrenaline and adrenaline. These receptors mediate several important physiological functions being ...
The role of keratins in proliferation, differentiation and hypoxia signaling in colonic epithelia
(Åbo Akademi - Åbo Akademi University, 2018-08-17)
Keratin (K) intermediate filament proteins are important in stress protection and in providing mechanical support to colonic epithelial cells. Deletion of K8 in mice (K8-/-) leads to colonic epithelial hyperproliferation, ...
Regulation of cellular stress proteins in physiology and disease
(Åbo Akademi - Åbo Akademi University, 2018-05-18)
All cells in a human body are constantly exposed to environmental fluctuations to which the cells must respond. Most of the cellular responses are mediated by proteins that are specifically regulated according to the ...
Removal of cyanobacterial toxins by strains of probiotic bacteria
(Åbo Akademi - Åbo Akademi University, 2011-12-21)
VAP-1 as drug target in inflammation : structural features determining ligand interactions
(Åbo Akademi - Åbo Akademi University, 2015-12-05)
Vascular adhesion protein-1 (VAP-1), which belongs to the copper amine oxidases (CAOs), is a validated drug target in inflammatory diseases. Inhibition of VAP-1 blocks the leukocyte trafficking to sites of inflammation and ...
Nanoparticles as Targeting System for Cancer Treatment : From idea towards reality
(Åbo Akademi - Åbo Akademi University, 2019-09-20)
To be able to target cells of interest is one of the key aims in medicine today, because it could minimize side effects of drugs. This is of special importance in cancer therapies, were the treatment has serious side-effects ...