Haku
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Membrane properties of structurally modified ceramides : effects on lipid lateral distribution and sphingomyelin-interactions in artificial bilayer membranes
(Åbo Akademi - Åbo Akademi University, 2014-03-14)
Ceramides comprise a class of sphingolipids that exist only in small amounts
in cellular membranes, but which have been associated with important roles in
cellular signaling processes. The influences that ceramides have ...
Choosing the target loci : heat shock factors HSF1 and HSF2 as regulators of cell stress and development
(Åbo Akademi - Åbo Akademi University, 2014-08-29)
Heat shock factors (HSFs) are an evolutionarily well conserved family of transcription factors that coordinate stress-induced gene expression and direct versatile physiological processes in eukaryote organisms. The ...
Muscarinic toxins : characterization of adrenoceptor binding and applicability of membrane anchoring via glycosylphosphatidylinositol tail
(Åbo Akademi - Åbo Akademi University, 2014-01-31)
Adrenoceptors (ARs), G-protein coupled receptors (GPCRs) at the plasma membrane, respond to endogenous catecholamines noradrenaline and adrenaline. These receptors mediate several important physiological functions being ...
Studies on membrane properties of cholesterol and 3-beta modified sterol analogs
(Åbo Akademi - Åbo Akademi University, 2014-11-28)
Cholesterol (Chol) is an important lipid in cellular membranes functioning both as a membrane fluidity regulator, permeability regulator and co-factor for some membrane proteins, e.g. G-protein coupled receptors. It also ...
Regulation of HSF2 and its function in mitosis
(Åbo Akademi - Åbo Akademi University, 2014-09-26)
The cell is continuously subjected to various forms of external and intrinsic proteindamaging stresses, including hyperthermia, pathophysiological states, as well as cell differentiation and proliferation. Proteindamaging ...
Tuning cell motility : roles of nestin and vimentin in cancer cell invasion and motility
(Åbo Akademi - Åbo Akademi University, 2014-05-16)
The cytoskeleton is a key feature of both prokaryotic and eukaryotic cells. Itis comprised of three protein families, one of which is the intermediate filaments (IFs). Of these, the IFs are the largest and most diverse. ...
Structural studies and in vivo characterisation of Oct4:PORE and Oct4/Sox2:UTF1 complexes
(Åbo Akademi - Åbo Akademi University, 2014-06-03)
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