Haku
Viitteet 21-30 / 40
JNK, a versatile regulator of kinesin-1 transport and cytoskeleton dynamics
(Åbo Akademi - Åbo Akademi University, 2013-02-11)
C-Jun N-terminal kinase (JNK) is traditionally recognized as a crucial factor in stress response and inducer of apoptosis upon various stimulations. Three isoforms build the JNK subfamily of MAPK; generally expressed JNK1 ...
Dynamic interplay between the intermediate filament protein nestin and Cyclin-dependent kinase 5
(Åbo Akademi - Åbo Akademi University, 2010-10-29)
Role of the canonical transient receptor potential channel 2 (TRPC2) in thyroid cell function
(Åbo Akademi - Åbo Akademi University, 2013-02-08)
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Regulation of HSF2 and its function in mitosis
(Åbo Akademi - Åbo Akademi University, 2014-09-26)
The cell is continuously subjected to various forms of external and intrinsic proteindamaging stresses, including hyperthermia, pathophysiological states, as well as cell differentiation and proliferation. Proteindamaging ...
To divide or differentiate? : nestin-mediated regulation of Cdk5 in cell fate decisions
(Åbo Akademi - Åbo Akademi University, 2015-06-30)
The molecular functions of the non-cell cycle-related Cyclin-dependent kinase 5 (Cdk5) have been of primary interest within the neuroscience field, but novel undertakings are constantly emerging for the kinase in tissue ...
Targeting oncogenic signaling proteins : new insights using a FRET-based chemical biology approach
(Åbo Akademi - Åbo Akademi University, 2016-01-15)
Cancer affects more than 20 million people each year and this rate is increasing globally. The Ras/MAPK-pathway is one of the best-studied cancer signaling pathways. Ras proteins are mutated in almost 20% of all human ...
Nanoclustering augmentation : a novel mechanism of Ras activation in cancer
(Åbo Akademi - Åbo Akademi University, 2016-02-12)
Proteins of the Ras family are central regulators of crucial cellular processes, such as proliferation, differentiation and apoptosis. Their importance is emphasized in cancer, in which the isoforms H-ras, N-ras and K-ras ...
Models to study intermediate filament dynamics and functions
(Åbo Akademi - Åbo Akademi University, 2016-01-08)
Intermediate filaments are part of the cytoskeleton and nucleoskeleton; they provide cells with structure and have important roles in cell signalling. The IFs are a large protein family with more than 70 members; each ...
Tuning cell motility : roles of nestin and vimentin in cancer cell invasion and motility
(Åbo Akademi - Åbo Akademi University, 2014-05-16)
The cytoskeleton is a key feature of both prokaryotic and eukaryotic cells. Itis comprised of three protein families, one of which is the intermediate filaments (IFs). Of these, the IFs are the largest and most diverse. ...
Structural studies and in vivo characterisation of Oct4:PORE and Oct4/Sox2:UTF1 complexes
(Åbo Akademi - Åbo Akademi University, 2014-06-03)
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