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Impact of lipid-lipid interactions on lateral segregation in bilayers
(Åbo Akademi - Åbo Akademi University, 2018-05-18)
The vast diversity of lipid species found in cells suggests that structural variation of lipids is essential for the normal function of the cell. One essential reason could be the formation of lateral heterogeneity in cell ...
The role of keratins in proliferation, differentiation and hypoxia signaling in colonic epithelia
(Åbo Akademi - Åbo Akademi University, 2018-08-17)
Keratin (K) intermediate filament proteins are important in stress protection and in providing mechanical support to colonic epithelial cells. Deletion of K8 in mice (K8-/-) leads to colonic epithelial hyperproliferation, ...
Bioinformatics Characterization of Amine Oxidases
(Åbo Akademi - Åbo Akademi University, 2018-12-14)
Amine oxidases catalyse the oxidative degradation of amines into the corresponding aldehyde, ammonia and hydrogen peroxide. They can be classified into different subfamilies based on the prosthetic group: (1) proteins with ...
Regulation of cellular stress proteins in physiology and disease
(Åbo Akademi - Åbo Akademi University, 2018-05-18)
All cells in a human body are constantly exposed to environmental fluctuations to which the cells must respond. Most of the cellular responses are mediated by proteins that are specifically regulated according to the ...
Keratiner i den endokrina bukspottkörteln : Nya regulatorer av cellulära processer i β-celler
(Åbo Akademi - Åbo Akademi University, 2018-02-09)
Muscarinic toxins : characterization of adrenoceptor binding and applicability of membrane anchoring via glycosylphosphatidylinositol tail
(Åbo Akademi - Åbo Akademi University, 2014-01-31)
Adrenoceptors (ARs), G-protein coupled receptors (GPCRs) at the plasma membrane, respond to endogenous catecholamines noradrenaline and adrenaline. These receptors mediate several important physiological functions being ...
Role and regulatory mechanisms of heat shock factor 2
(Åbo Akademi - Åbo Akademi University, 2011-11-04)
Protein homeostasis is essential for cells to prosper and survive. Various forms of stress, such as elevated temperatures, oxidative stress, heavy metals or bacterial infections cause protein damage, which might lead to ...
Lethal weapons : novel approaches for receptor-targeted cancer cell elimination
(Åbo Akademi - Åbo Akademi University, 2010-12-17)
The currently used forms of cancer therapy are associated with drug resistance and toxicity to healthy tissues. Thus, more efficient methods are needed for cancer-specific induction of growth arrest and programmed cell ...
TR(i)P, TR(i)P, hooray : new functions for TRPC2 and TRPC3
(Åbo Akademi - Åbo Akademi University, 2012-09-14)
JNK, a versatile regulator of kinesin-1 transport and cytoskeleton dynamics
(Åbo Akademi - Åbo Akademi University, 2013-02-11)
C-Jun N-terminal kinase (JNK) is traditionally recognized as a crucial factor in stress response and inducer of apoptosis upon various stimulations. Three isoforms build the JNK subfamily of MAPK; generally expressed JNK1 ...