Haku
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Membrane properties of structurally modified ceramides : effects on lipid lateral distribution and sphingomyelin-interactions in artificial bilayer membranes
(Åbo Akademi - Åbo Akademi University, 2014-03-14)
Ceramides comprise a class of sphingolipids that exist only in small amounts
in cellular membranes, but which have been associated with important roles in
cellular signaling processes. The influences that ceramides have ...
Regulation of Death Receptor Responses by Hyperthermia
(Åbo Akademi - Åbo Akademi University, 2007-06-01)
Cells need a variety of responses to protect themselves against stresses caused by changes in the environment. Likewise, a complex apoptotic machinery is necessary for elimination of cells that are no longer needed in the ...
Identification of Three Conserved Interaction Zones Around the Catalytic Machinery of alpha/beta- Hydrolase Fold Enzymes
(Åbo Akademi - Åbo Akademi University, 2020-03-06)
The alpha/beta-Hydrolases (ABH) comprise one of the largest structural families of proteins, found in all organisms. Although they share low sequence similarity, the ABH fold enzymes maintain a common catalytic domain, the ...
Phosphorylation as a mediator of protein function in cell migration, differentiation, and death : vimentin, AATF, and Par-4 in the spotlight
(Åbo Akademi - Åbo Akademi University, 2016-11-11)
Protein phosphorylation is a major regulator of cellular signaling. It functions when a kinase joins a phosphate group to a protein, or when a phosphatase strips off a phosphate group from serine, threonine, or tyrosine ...
Prediction of 3D structure and ligand-binding properties : ABC transporters and flavodiiron proteins from Synechocystis sp. strain PCC 6803
(Åbo Akademi - Åbo Akademi University, 2013-05-24)
Cyanobacteria are unicellular, non-nitrogen-fixing prokaryotes, which perform photosynthesis similarly as higher plants. The cyanobacterium Synechocystis sp. strain PCC 6803 is used as a model organism in photosynthesis ...
Biogeochemistry in acid sulphate soil landscapes and small urban centres in Western Finland
(Åbo Akademi - Åbo Akademi University, 2010-01-29)
The overall purpose of this thesis was to increase the knowledge on the biogeochemistry of rural acid sulphate (AS) soil environments and urban forest ecosystems near small towns in Western Finland. In addition, the potential ...
Effects of methylation and hydroxylation of sphingomyelins on their biophysical properties and interactions with cholesterol
(Åbo Akademi - Åbo Akademi University, 2012-09-28)
Glycolipid and ceramide transfer proteins : important determinants for their function
(Åbo Akademi - Åbo Akademi University, 2013-04-12)
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Structural characterization of avidins with novel binding properties
(Åbo Akademi - Åbo Akademi University, 2018-09-14)
Avidin (Avd) is a protein first discovered in chicken egg white, and later in other birds, reptiles, amphibians and lancelet. Apart from these eukaryoticspecies, Avd is also identified in few fungal and in many bacterial ...
Studies on Ceramide/Colipid Interactions in Complex Bilayers
(Åbo Akademi - Åbo Akademi University, 2017-12-01)
Ceramide belongs to an important class of sphingolipids and it constitutes the hydrophobic backbone of all complex sphingolipids. Ceramide plays an important role in different biological processes such as cell signaling, ...