Haku
Viitteet 1-6 / 6
Novel cancer-related regulatory targets for the signalling sphingolipids sphingosine-1-phosphate and sphingosylphosphorylcholine
(Åbo Akademi - Åbo Akademi University, 2016-04-29)
The signalling sphingolipid sphingosine-1-phosphate (S1P) is necessary for development of the immune system and vasculature and on a cellular level regulates migration, proliferation and survival. Due to these traits S1P ...
Structure in stress management : Keratins in intestinal stress protection
(Åbo Akademi - Åbo Akademi University, 2016-12-16)
Intermediate filaments (IFs), a major constituent of the cellular cytoskeleton, contribute mainly to the mechanical stability of the cell. Simple epithelial keratins (SEKs) are IF proteins expressed in the single-layered ...
Targeting oncogenic signaling proteins : new insights using a FRET-based chemical biology approach
(Åbo Akademi - Åbo Akademi University, 2016-01-15)
Cancer affects more than 20 million people each year and this rate is increasing globally. The Ras/MAPK-pathway is one of the best-studied cancer signaling pathways. Ras proteins are mutated in almost 20% of all human ...
Nanoclustering augmentation : a novel mechanism of Ras activation in cancer
(Åbo Akademi - Åbo Akademi University, 2016-02-12)
Proteins of the Ras family are central regulators of crucial cellular processes, such as proliferation, differentiation and apoptosis. Their importance is emphasized in cancer, in which the isoforms H-ras, N-ras and K-ras ...
Models to study intermediate filament dynamics and functions
(Åbo Akademi - Åbo Akademi University, 2016-01-08)
Intermediate filaments are part of the cytoskeleton and nucleoskeleton; they provide cells with structure and have important roles in cell signalling. The IFs are a large protein family with more than 70 members; each ...
The role of keratin intermediate filaments in the colon epithelial cells
(Åbo Akademi - Åbo Akademi University, 2016-02-18)
Keratins (K) are cytoskeletal proteins mainly expressed in the epithelium and constitute the largest subgroup of intermediate filaments (IFs). Simple epithelial keratins (SEKs) K7-K8 and K18-K20 are the major IF elements ...