Haku
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Sphingosine-1-phosphate-evoked invasion of follicular thyroid cancer cells : evidence for the involvement of HIF-I?, MMP2 and MMP9
(Åbo Akademi - Åbo Akademi University, 2015-09-11)
Sphingolipids are widely expressed molecules, which traditionally were considered to have majorly structural properties. Nowadays, however, they are implicated in a wide range of different biological processes. The bioactive ...
Networking Notch : regulation of Notch traffic and signaling crosstalk
(Åbo Akademi - Åbo Akademi University, 2015-10-13)
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Choosing the target loci : heat shock factors HSF1 and HSF2 as regulators of cell stress and development
(Åbo Akademi - Åbo Akademi University, 2014-08-29)
Heat shock factors (HSFs) are an evolutionarily well conserved family of transcription factors that coordinate stress-induced gene expression and direct versatile physiological processes in eukaryote organisms. The ...
Regulation of cell fate by c-FLIP phosphorylation
(Åbo Akademi - Åbo Akademi University, 2013-12-13)
Programmed cell death is an important physiological cellular process that maintains homeostasis and protects multicellular organisms from diseases. Apoptosis is the principal mode of cell death, which eliminates unwanted ...
Novel cancer-related regulatory targets for the signalling sphingolipids sphingosine-1-phosphate and sphingosylphosphorylcholine
(Åbo Akademi - Åbo Akademi University, 2016-04-29)
The signalling sphingolipid sphingosine-1-phosphate (S1P) is necessary for development of the immune system and vasculature and on a cellular level regulates migration, proliferation and survival. Due to these traits S1P ...
Stress management : multilayer regulation of the heat shock response
(Åbo Akademi - Åbo Akademi University, 2017-04-21)
Protein-damaging stresses, such as exposure to elevated temperature, alcohol, and heavy metals and microbial infections, increase the amount of misfolded proteins in cells, which may lead to formation of toxic protein ...
Structure in stress management : Keratins in intestinal stress protection
(Åbo Akademi - Åbo Akademi University, 2016-12-16)
Intermediate filaments (IFs), a major constituent of the cellular cytoskeleton, contribute mainly to the mechanical stability of the cell. Simple epithelial keratins (SEKs) are IF proteins expressed in the single-layered ...
On the Evolution, Function and Pathogenesis of Intermediate Filaments
(Åbo Akademi - Åbo Akademi University, 2017-06-02)
Intermediärfilament (IF) är nukleära och cytoplasmiska strukturprotein. I människans genom ingår 70 gener som kodar för 74 hittills kända intermediärfilament. Mutationer i dessa gener orsakar många allvarliga sjukdomar. ...
Cellular responses to stress and kinase signaling activation : apoptosis and differentiation
(Åbo Akademi - Åbo Akademi University, 2013-08-13)
Stress signals are often sensed by membrane-bound proteins which translate signals into the chemical modification of molecules, most notably protein kinases. These kinases, in turn, transmit the decoded message through a ...
Kinase function in Parkinson’s disease and neuronal transport
(Åbo Akademi - Åbo Akademi University, 2017-11-03)