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Identification of Three Conserved Interaction Zones Around the Catalytic Machinery of alpha/beta- Hydrolase Fold Enzymes
(Åbo Akademi - Åbo Akademi University, 2020-03-06)
The alpha/beta-Hydrolases (ABH) comprise one of the largest structural families of proteins, found in all organisms. Although they share low sequence similarity, the ABH fold enzymes maintain a common catalytic domain, the ...
Molecular Basis of the Sticholysin-Membrane Interaction : On the Structure of the Pore and the Effects of Lipids
(Åbo Akademi University
Universidad Complutense de Madrid, 2021-06-18)
The usefulness of toxicity across the tree of life is far beyond doubt. Most, if not all, organisms produce compounds that can be used for attack and/or defense against external entities. Some of the most specialized of ...
The Dynamic Structural Effects of Activating ERBB Kinase Somatic Mutations
(Åbo Akademi University, 2021-10-15)
The ERBB family of receptor tyrosine kinases, epidermal growth factor receptor (EGFR, ERBB1), ERBB2, ERBB3 and ERBB4, are transmembrane signaling proteins that regulate cellular processes such as cell survival, mobility, ...
Membrane lipid frustration : Contribution of ceramide and its effects on lateral segregation
(Åbo Akademi University, 2021-06-17)
Ceramides are both sphingolipid precursor molecules and breakdown products with effects on membranes that are of interest both from biophysical and physiological points of view. When present in a membrane, ceramide induces ...
Virulence and survival mechanisms in Borrelia and Klebsiella infections – a structural bioinformatics perspective
(Åbo Akademi University, 2021-06-23)
Bacteria use a wide variety of mechanisms to establish an infection in their host and to compete with other microorganisms for space and nutrients. These virulence and survival mechanisms mainly rely on the functions of ...