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Sphingosine 1-phosphate receptor 2 and the trpc1 ion channel as regulators of human thyroid cancer cell migration and proliferation
(Åbo Akademi - Åbo Akademi University, 2017-09-22)
Thyroid cancer is the most common endocrine cancer and currently there is no effective treatment available against the most aggressive and highly invasive forms of thyroid cancer. Sphingosine 1-phosphate (S1P) is a bioactive ...
The role of keratins in proliferation, differentiation and hypoxia signaling in colonic epithelia
(Åbo Akademi - Åbo Akademi University, 2018-08-17)
Keratin (K) intermediate filament proteins are important in stress protection and in providing mechanical support to colonic epithelial cells. Deletion of K8 in mice (K8-/-) leads to colonic epithelial hyperproliferation, ...
The role of keratin intermediate filaments in the colon epithelial cells
(Åbo Akademi - Åbo Akademi University, 2016-02-18)
Keratins (K) are cytoskeletal proteins mainly expressed in the epithelium and constitute the largest subgroup of intermediate filaments (IFs). Simple epithelial keratins (SEKs) K7-K8 and K18-K20 are the major IF elements ...
TR(i)P, TR(i)P, hooray : new functions for TRPC2 and TRPC3
(Åbo Akademi - Åbo Akademi University, 2012-09-14)
Models to study intermediate filament dynamics and functions
(Åbo Akademi - Åbo Akademi University, 2016-01-08)
Intermediate filaments are part of the cytoskeleton and nucleoskeleton; they provide cells with structure and have important roles in cell signalling. The IFs are a large protein family with more than 70 members; each ...
On the evolution, function and pathogenesis of intermediate filaments
(Åbo Akademi - Åbo Akademi University, 2017-06-02)
Sphingosine-1-phosphate-evoked invasion of follicular thyroid cancer cells : evidence for the involvement of HIF-I?, MMP2 and MMP9
(Åbo Akademi - Åbo Akademi University, 2015-09-11)
Sphingolipids are widely expressed molecules, which traditionally were considered to have majorly structural properties. Nowadays, however, they are implicated in a wide range of different biological processes. The bioactive ...
Assessment of endocrine disrupting activities in the aquatic environment
(Åbo Akademi - Åbo Akademi University, 2009-01-16)
Hormonstörande ämnen är syntetiska eller naturliga ämnen som stör organismers hormonsystem och bidrar till könsförvirring och sterilitet. Sådana ämnen kommer i ökande takt ut i vattenmiljön genom rester av läkemedel, ...
Networking Notch : regulation of Notch traffic and signaling crosstalk
(Åbo Akademi - Åbo Akademi University, 2015-10-13)
Role and regulatory mechanisms of heat shock factor 2
(Åbo Akademi - Åbo Akademi University, 2011-11-04)
Protein homeostasis is essential for cells to prosper and survive. Various forms of stress, such as elevated temperatures, oxidative stress, heavy metals or bacterial infections cause protein damage, which might lead to ...