Viitteet 1-10 / 62
Tuning cell motility : roles of nestin and vimentin in cancer cell invasion and motility
(Åbo Akademi University, 2014-05-16)
The cytoskeleton is a key feature of both prokaryotic and eukaryotic cells. Itis comprised of three protein families, one of which is the intermediate filaments (IFs). Of these, the IFs are the largest and most diverse. ...
Choosing the target loci : heat shock factors HSF1 and HSF2 as regulators of cell stress and development
(Åbo Akademi University, 2014-08-29)
Heat shock factors (HSFs) are an evolutionarily well conserved family of transcription factors that coordinate stress-induced gene expression and direct versatile physiological processes in eukaryote organisms. The ...
Selective inhibition of human tankyrases
(Åbo Akademi University, 2014-03-28)
Tankyrases belong to the Diphtheria toxin-like ADP-ribosyltransferase (ARTD) enzyme superfamily, also known as poly(ADP-ribose) polymerases (PARPs). They catalyze a covalent post-translational modification reaction where ...
Structural studies and in vivo characterisation of Oct4:PORE and Oct4/Sox2:UTF1 complexes
(Åbo Akademi University, 2014-06-03)
Membrane properties of structurally modified ceramides : effects on lipid lateral distribution and sphingomyelin-interactions in artificial bilayer membranes
(Åbo Akademi University, 2014-03-14)
Ceramides comprise a class of sphingolipids that exist only in small amounts in cellular membranes, but which have been associated with important roles in cellular signaling processes. The influences that ceramides have ...
Studies on membrane properties of cholesterol and 3-beta modified sterol analogs
(Åbo Akademi University, 2014-11-28)
Cholesterol (Chol) is an important lipid in cellular membranes functioning both as a membrane fluidity regulator, permeability regulator and co-factor for some membrane proteins, e.g. G-protein coupled receptors. It also ...
Muscarinic toxins : characterization of adrenoceptor binding and applicability of membrane anchoring via glycosylphosphatidylinositol tail
(Åbo Akademi University, 2014-01-31)
Adrenoceptors (ARs), G-protein coupled receptors (GPCRs) at the plasma membrane, respond to endogenous catecholamines noradrenaline and adrenaline. These receptors mediate several important physiological functions being ...
Context-specific independence in graphical models
(Åbo Akademi University, 2014-11-21)
The theme of this thesis is context-speci c independence in graphical models. Considering a system of stochastic variables it is often the case that the variables are dependent of each other. This can, for instance, be ...
Cost-efficient virtual machine management : provisioning, admission control, and consolidation
(Turku Centre for Computer Science, 2014-10-09)
One of the main challenges in Software Engineering is to cope with the transition from an industry based on software as a product to software as a service. The field of Software Engineering should provide the necessary ...
Scheduling dynamic dataflow graphs with model checking
(Turku Centre for Computer Science, 2014-08-15)
With the shift towards many-core computer architectures, dataflow programming has been proposed as one potential solution for producing software that scales to a varying number of processor cores. Programming for parallel ...