Selaus nimekkeen mukaan kokoelmassa 1182 Biokemia, solu- ja molekyylibiologia
Viitteet 61-73 / 73
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Targeting oncogenic signaling proteins : new insights using a FRET-based chemical biology approach
(Åbo Akademi - Åbo Akademi University, 15.01.2016)Cancer affects more than 20 million people each year and this rate is increasing globally. The Ras/MAPK-pathway is one of the best-studied cancer signaling pathways. Ras proteins are mutated in almost 20% of all human ... -
The Dynamic Structural Effects of Activating ERBB Kinase Somatic Mutations
(Åbo Akademi University, 15.10.2021)The ERBB family of receptor tyrosine kinases, epidermal growth factor receptor (EGFR, ERBB1), ERBB2, ERBB3 and ERBB4, are transmembrane signaling proteins that regulate cellular processes such as cell survival, mobility, ... -
The regulatory role of butyrolactone I in the filamentous fungus Aspergillus terreus
(Åbo Akademi - Åbo Akademi University, 08.06.2018)An industrially and pharmaceutically important filamentous fungus, Aspergillus terreus, is known to biosynthesise plentiful natural products including lovastatin, a serum cholesterol lowering agent. A. terreus has also ... -
The Role of Exosomal Vimentin in Mediating Wound Healing
(Åbo Akademi - Åbo Akademi University, 16.11.2022)Despite great advances in tissue engineering and regenerative medicine,impaired wound healing is still a challenging clinical problem. Accumulating evidence demonstrates the ability of extracellular vesicles and specifically, ... -
The role of keratin intermediate filaments in the colon epithelial cells
(Åbo Akademi - Åbo Akademi University, 18.02.2016)Keratins (K) are cytoskeletal proteins mainly expressed in the epithelium and constitute the largest subgroup of intermediate filaments (IFs). Simple epithelial keratins (SEKs) K7-K8 and K18-K20 are the major IF elements ... -
The role of keratins in proliferation, differentiation and hypoxia signaling in colonic epithelia
(Åbo Akademi - Åbo Akademi University, 17.08.2018)Keratin (K) intermediate filament proteins are important in stress protection and in providing mechanical support to colonic epithelial cells. Deletion of K8 in mice (K8-/-) leads to colonic epithelial hyperproliferation, ... -
The Role of Vimentin in Tissue Repair and Cell Growth
(Åbo Akademi - Åbo Akademi University, 10.03.2023)Microfilaments, microtubules, and intermediate filaments serve as the cytoskeleton of the cell and form a complex network by interacting with cytoskeleton-associated proteins. The cytoskeleton provides a framework for the ... -
To divide or differentiate? : nestin-mediated regulation of Cdk5 in cell fate decisions
(Åbo Akademi - Åbo Akademi University, 30.06.2015)The molecular functions of the non-cell cycle-related Cyclin-dependent kinase 5 (Cdk5) have been of primary interest within the neuroscience field, but novel undertakings are constantly emerging for the kinase in tissue ... -
TR(i)P, TR(i)P, hooray : new functions for TRPC2 and TRPC3
(Åbo Akademi - Åbo Akademi University, 14.09.2012) -
Tuning cell motility : roles of nestin and vimentin in cancer cell invasion and motility
(Åbo Akademi - Åbo Akademi University, 16.05.2014)The cytoskeleton is a key feature of both prokaryotic and eukaryotic cells. Itis comprised of three protein families, one of which is the intermediate filaments (IFs). Of these, the IFs are the largest and most diverse. ... -
VAP-1 as drug target in inflammation : structural features determining ligand interactions
(Åbo Akademi - Åbo Akademi University, 05.12.2015)Vascular adhesion protein-1 (VAP-1), which belongs to the copper amine oxidases (CAOs), is a validated drug target in inflammatory diseases. Inhibition of VAP-1 blocks the leukocyte trafficking to sites of inflammation and ... -
Vimentin links hemodynamic forces and Notch signaling in vascular tissue remodeling
(Åbo Akademi University, 09.07.2021) -
Virulence and survival mechanisms in Borrelia and Klebsiella infections – a structural bioinformatics perspective
(Åbo Akademi University, 23.06.2021)Bacteria use a wide variety of mechanisms to establish an infection in their host and to compete with other microorganisms for space and nutrients. These virulence and survival mechanisms mainly rely on the functions of ...