Selaus nimekkeen mukaan kokoelmassa 1182 Biokemia, solu- ja molekyylibiologia
Viitteet 50-69 / 73
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Selective inhibition of human tankyrases
(Åbo Akademi - Åbo Akademi University, 28.03.2014)Tankyrases belong to the Diphtheria toxin-like ADP-ribosyltransferase (ARTD) enzyme superfamily, also known as poly(ADP-ribose) polymerases (PARPs). They catalyze a covalent post-translational modification reaction where ... -
Spatial control of angiogenesis by engineered patterns of Notch ligands
(Åbo Akademi - Åbo Akademi University, 04.10.2022)Spatial control of angiogenesis by engineered patterns of Notch In tissue engineering and regenerative medicine, proper vascularization of engineered tissues is imperative, as diffusion of nutrients, oxygen and waste is ... -
Specificity Determining Features at the Interface of Biomolecular Complexes as Regulators of Biological Functions
(Åbo Akademi - Åbo Akademi University, 13.01.2023)Amino acid residues at the biomolecular interface play essential roles in many biological and cellular processes; relevant to this thesis, protein-protein interactions regulate signaling pathways and enzymatic activity, ... -
Sphingosine 1-phosphate receptor 2 and the trpc1 ion channel as regulators of human thyroid cancer cell migration and proliferation
(Åbo Akademi - Åbo Akademi University, 22.09.2017)Thyroid cancer is the most common endocrine cancer and currently there is no effective treatment available against the most aggressive and highly invasive forms of thyroid cancer. Sphingosine 1-phosphate (S1P) is a bioactive ... -
Sphingosine-1-phosphate-evoked invasion of follicular thyroid cancer cells : evidence for the involvement of HIF-I?, MMP2 and MMP9
(Åbo Akademi - Åbo Akademi University, 11.09.2015)Sphingolipids are widely expressed molecules, which traditionally were considered to have majorly structural properties. Nowadays, however, they are implicated in a wide range of different biological processes. The bioactive ... -
Stress management : multilayer regulation of the heat shock response
(Åbo Akademi - Åbo Akademi University, 21.04.2017)Protein-damaging stresses, such as exposure to elevated temperature, alcohol, and heavy metals and microbial infections, increase the amount of misfolded proteins in cells, which may lead to formation of toxic protein ... -
Structural characterization of avidins with novel binding properties
(Åbo Akademi - Åbo Akademi University, 14.09.2018)Avidin (Avd) is a protein first discovered in chicken egg white, and later in other birds, reptiles, amphibians and lancelet. Apart from these eukaryoticspecies, Avd is also identified in few fungal and in many bacterial ... -
Structural studies and in vivo characterisation of Oct4:PORE and Oct4/Sox2:UTF1 complexes
(Åbo Akademi - Åbo Akademi University, 03.06.2014)- -
Structure in stress management : Keratins in intestinal stress protection
(Åbo Akademi - Åbo Akademi University, 16.12.2016)Intermediate filaments (IFs), a major constituent of the cellular cytoskeleton, contribute mainly to the mechanical stability of the cell. Simple epithelial keratins (SEKs) are IF proteins expressed in the single-layered ... -
Studies on Ceramide/Colipid Interactions in Complex Bilayers
(Åbo Akademi - Åbo Akademi University, 01.12.2017)Ceramide belongs to an important class of sphingolipids and it constitutes the hydrophobic backbone of all complex sphingolipids. Ceramide plays an important role in different biological processes such as cell signaling, ... -
Studies on membrane properties of cholesterol and 3-beta modified sterol analogs
(Åbo Akademi - Åbo Akademi University, 28.11.2014)Cholesterol (Chol) is an important lipid in cellular membranes functioning both as a membrane fluidity regulator, permeability regulator and co-factor for some membrane proteins, e.g. G-protein coupled receptors. It also ... -
Targeting oncogenic signaling proteins : new insights using a FRET-based chemical biology approach
(Åbo Akademi - Åbo Akademi University, 15.01.2016)Cancer affects more than 20 million people each year and this rate is increasing globally. The Ras/MAPK-pathway is one of the best-studied cancer signaling pathways. Ras proteins are mutated in almost 20% of all human ... -
The Dynamic Structural Effects of Activating ERBB Kinase Somatic Mutations
(Åbo Akademi University, 15.10.2021)The ERBB family of receptor tyrosine kinases, epidermal growth factor receptor (EGFR, ERBB1), ERBB2, ERBB3 and ERBB4, are transmembrane signaling proteins that regulate cellular processes such as cell survival, mobility, ... -
The regulatory role of butyrolactone I in the filamentous fungus Aspergillus terreus
(Åbo Akademi - Åbo Akademi University, 08.06.2018)An industrially and pharmaceutically important filamentous fungus, Aspergillus terreus, is known to biosynthesise plentiful natural products including lovastatin, a serum cholesterol lowering agent. A. terreus has also ... -
The Role of Exosomal Vimentin in Mediating Wound Healing
(Åbo Akademi - Åbo Akademi University, 16.11.2022)Despite great advances in tissue engineering and regenerative medicine,impaired wound healing is still a challenging clinical problem. Accumulating evidence demonstrates the ability of extracellular vesicles and specifically, ... -
The role of keratin intermediate filaments in the colon epithelial cells
(Åbo Akademi - Åbo Akademi University, 18.02.2016)Keratins (K) are cytoskeletal proteins mainly expressed in the epithelium and constitute the largest subgroup of intermediate filaments (IFs). Simple epithelial keratins (SEKs) K7-K8 and K18-K20 are the major IF elements ... -
The role of keratins in proliferation, differentiation and hypoxia signaling in colonic epithelia
(Åbo Akademi - Åbo Akademi University, 17.08.2018)Keratin (K) intermediate filament proteins are important in stress protection and in providing mechanical support to colonic epithelial cells. Deletion of K8 in mice (K8-/-) leads to colonic epithelial hyperproliferation, ... -
The Role of Vimentin in Tissue Repair and Cell Growth
(Åbo Akademi - Åbo Akademi University, 10.03.2023)Microfilaments, microtubules, and intermediate filaments serve as the cytoskeleton of the cell and form a complex network by interacting with cytoskeleton-associated proteins. The cytoskeleton provides a framework for the ... -
To divide or differentiate? : nestin-mediated regulation of Cdk5 in cell fate decisions
(Åbo Akademi - Åbo Akademi University, 30.06.2015)The molecular functions of the non-cell cycle-related Cyclin-dependent kinase 5 (Cdk5) have been of primary interest within the neuroscience field, but novel undertakings are constantly emerging for the kinase in tissue ... -
TR(i)P, TR(i)P, hooray : new functions for TRPC2 and TRPC3
(Åbo Akademi - Åbo Akademi University, 14.09.2012)