Selaus nimekkeen mukaan kokoelmassa 1182 Biokemia, solu- ja molekyylibiologia
Viitteet 33-52 / 73
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Nanoclustering augmentation : a novel mechanism of Ras activation in cancer
(Åbo Akademi - Åbo Akademi University, 12.02.2016)Proteins of the Ras family are central regulators of crucial cellular processes, such as proliferation, differentiation and apoptosis. Their importance is emphasized in cancer, in which the isoforms H-ras, N-ras and K-ras ... -
Nanoparticles as Targeting System for Cancer Treatment : From idea towards reality
(Åbo Akademi - Åbo Akademi University, 20.09.2019)To be able to target cells of interest is one of the key aims in medicine today, because it could minimize side effects of drugs. This is of special importance in cancer therapies, were the treatment has serious side-effects ... -
Networking Notch : regulation of Notch traffic and signaling crosstalk
(Åbo Akademi - Åbo Akademi University, 13.10.2015)- -
Novel cancer-related regulatory targets for the signalling sphingolipids sphingosine-1-phosphate and sphingosylphosphorylcholine
(Åbo Akademi - Åbo Akademi University, 29.04.2016)The signalling sphingolipid sphingosine-1-phosphate (S1P) is necessary for development of the immune system and vasculature and on a cellular level regulates migration, proliferation and survival. Due to these traits S1P ... -
On the Evolution, Function and Pathogenesis of Intermediate Filaments
(Åbo Akademi - Åbo Akademi University, 02.06.2017)Intermediärfilament (IF) är nukleära och cytoplasmiska strukturprotein. I människans genom ingår 70 gener som kodar för 74 hittills kända intermediärfilament. Mutationer i dessa gener orsakar många allvarliga sjukdomar. ... -
Phosphorylation as a mediator of protein function in cell migration, differentiation, and death : vimentin, AATF, and Par-4 in the spotlight
(Åbo Akademi - Åbo Akademi University, 11.11.2016)Protein phosphorylation is a major regulator of cellular signaling. It functions when a kinase joins a phosphate group to a protein, or when a phosphatase strips off a phosphate group from serine, threonine, or tyrosine ... -
Prediction of 3D structure and ligand-binding properties : ABC transporters and flavodiiron proteins from Synechocystis sp. strain PCC 6803
(Åbo Akademi - Åbo Akademi University, 24.05.2013)Cyanobacteria are unicellular, non-nitrogen-fixing prokaryotes, which perform photosynthesis similarly as higher plants. The cyanobacterium Synechocystis sp. strain PCC 6803 is used as a model organism in photosynthesis ... -
Regulation of cell fate by c-FLIP phosphorylation
(Åbo Akademi - Åbo Akademi University, 13.12.2013)Programmed cell death is an important physiological cellular process that maintains homeostasis and protects multicellular organisms from diseases. Apoptosis is the principal mode of cell death, which eliminates unwanted ... -
Regulation of cellular stress proteins in physiology and disease
(Åbo Akademi - Åbo Akademi University, 18.05.2018)All cells in a human body are constantly exposed to environmental fluctuations to which the cells must respond. Most of the cellular responses are mediated by proteins that are specifically regulated according to the ... -
Regulation of Death Receptor Responses by Hyperthermia
(Åbo Akademi - Åbo Akademi University, 01.06.2007)Cells need a variety of responses to protect themselves against stresses caused by changes in the environment. Likewise, a complex apoptotic machinery is necessary for elimination of cells that are no longer needed in the ... -
Regulation of Host-Microbe Interactions and Inflammatory Signalling in Drosophila melanogaster
(Åbo Akademi University, 10.12.2021)In order to eliminate harmful pathogens, while allowing beneficial microbes to persist, inflammatory signalling in the intestine needs to be carefully regulated. Overactive immune signalling can lead to chronic inflammation ... -
Regulation of HSF2 and its function in mitosis
(Åbo Akademi - Åbo Akademi University, 26.09.2014)The cell is continuously subjected to various forms of external and intrinsic proteindamaging stresses, including hyperthermia, pathophysiological states, as well as cell differentiation and proliferation. Proteindamaging ... -
Regulation of Inflammatory Signalling by Caspases and M1-linked Ubiquitin Chains in Drosophila melanogaster
(Åbo Akademi - Åbo Akademi University, 30.11.2023)The NF-κB family of transcription factors are master regulators of innate immune responses and their dysregulation can lead to chronic inflammation and cause diseases like inflammatory bowel disease and cancer. To treat ... -
Regulation of Notch Signaling by Intracellular Trafficking
(Åbo Akademi - Åbo Akademi University, 21.02.2020)The Notch signaling pathway is one of the essential mediators of cell-cell communication during development of multicellular organisms. Notch signaling is based on receptors and ligands that interact between neighboring ... -
Removal of cyanobacterial toxins by strains of probiotic bacteria
(Åbo Akademi - Åbo Akademi University, 21.12.2011) -
Role and regulatory mechanisms of heat shock factor 2
(Åbo Akademi - Åbo Akademi University, 04.11.2011)Protein homeostasis is essential for cells to prosper and survive. Various forms of stress, such as elevated temperatures, oxidative stress, heavy metals or bacterial infections cause protein damage, which might lead to ... -
Role of the canonical transient receptor potential channel 2 (TRPC2) in thyroid cell function
(Åbo Akademi - Åbo Akademi University, 08.02.2013)- -
Selective inhibition of human tankyrases
(Åbo Akademi - Åbo Akademi University, 28.03.2014)Tankyrases belong to the Diphtheria toxin-like ADP-ribosyltransferase (ARTD) enzyme superfamily, also known as poly(ADP-ribose) polymerases (PARPs). They catalyze a covalent post-translational modification reaction where ... -
Spatial control of angiogenesis by engineered patterns of Notch ligands
(Åbo Akademi - Åbo Akademi University, 04.10.2022)Spatial control of angiogenesis by engineered patterns of Notch In tissue engineering and regenerative medicine, proper vascularization of engineered tissues is imperative, as diffusion of nutrients, oxygen and waste is ... -
Specificity Determining Features at the Interface of Biomolecular Complexes as Regulators of Biological Functions
(Åbo Akademi - Åbo Akademi University, 13.01.2023)Amino acid residues at the biomolecular interface play essential roles in many biological and cellular processes; relevant to this thesis, protein-protein interactions regulate signaling pathways and enzymatic activity, ...