Selaus nimekkeen mukaan kokoelmassa 1182 Biokemia, solu- ja molekyylibiologia
Viitteet 10-29 / 73
-
Development of Novel Drugs Targeting Chaperones of Oncogenic K-Ras
(Åbo Akademi - Åbo Akademi University, 12.02.2021)KRAS mutations account globally for about one million deaths per year, but there is as yet no approved drug against KRAS. K-Ras proteins are organized into di-/oligomeric nanoscale signaling complexes, known as nanoclusters ... -
Dynamic interplay between the intermediate filament protein nestin and Cyclin-dependent kinase 5
(Åbo Akademi - Åbo Akademi University, 29.10.2010) -
Effects of methylation and hydroxylation of sphingomyelins on their biophysical properties and interactions with cholesterol
(Åbo Akademi - Åbo Akademi University, 28.09.2012) -
Fast LC-MS detection of cyanobacteria peptide hepatotoxins – method development for determination of total contamination levels in biological materials
(Åbo Akademi - Åbo Akademi University, 05.11.2010) -
From protein structure to function with bioinformatics
(Åbo Akademi - Åbo Akademi University, 27.11.2015)It has long been known that amino acids are the building blocks for proteins and govern their folding into specific three-dimensional structures. However, the details of this process are still unknown and represent one of ... -
Glycolipid and ceramide transfer proteins : important determinants for their function
(Åbo Akademi - Åbo Akademi University, 12.04.2013)- -
HSF1 and HSF2 in Stress and EMT-Associated Transcriptional Networks
(Åbo Akademi - Åbo Akademi University, 15.09.2023)Protein-damaging stress frequently occurs during the lifetime of a cell. To survive these insults, cells rely on the action of proteins called transcription factors that adjust the expression of genes, such as chaperones, ... -
Identification of Three Conserved Interaction Zones Around the Catalytic Machinery of alpha/beta- Hydrolase Fold Enzymes
(Åbo Akademi - Åbo Akademi University, 06.03.2020)The alpha/beta-Hydrolases (ABH) comprise one of the largest structural families of proteins, found in all organisms. Although they share low sequence similarity, the ABH fold enzymes maintain a common catalytic domain, the ... -
Impact of lipid-lipid interactions on lateral segregation in bilayers
(Åbo Akademi - Åbo Akademi University, 18.05.2018)The vast diversity of lipid species found in cells suggests that structural variation of lipids is essential for the normal function of the cell. One essential reason could be the formation of lateral heterogeneity in cell ... -
Integrin evolution : from prokaryotes to the diversification within chordates
(Åbo Akademi - Åbo Akademi University, 14.10.2016)Integrins are a family of large multi-domain cell surface receptors responsible for bidirectional signaling in response to cell-cell, cell-extracellular matrix interactions as well as intracellular interactions. Intrgrins ... -
Intertwining Cell Adhesion, Gene Expression, and Stress
(Åbo Akademi - Åbo Akademi University, 01.06.2023)Cells within an organism are constantly exposed to environmental insults that challenge the homeostasis of their proteome by causing protein misfolding. To survive these adverse situations, cells are equipped with a ... -
JNK, a versatile regulator of kinesin-1 transport and cytoskeleton dynamics
(Åbo Akademi - Åbo Akademi University, 11.02.2013)C-Jun N-terminal kinase (JNK) is traditionally recognized as a crucial factor in stress response and inducer of apoptosis upon various stimulations. Three isoforms build the JNK subfamily of MAPK; generally expressed JNK1 ... -
Keratiner i den endokrina bukspottkörteln : Nya regulatorer av cellulära processer i β-celler
(Åbo Akademi - Åbo Akademi University, 09.02.2018) -
Kinase function in Parkinson’s disease and neuronal transport
(Åbo Akademi - Åbo Akademi University, 03.11.2017) -
Lethal weapons : novel approaches for receptor-targeted cancer cell elimination
(Åbo Akademi - Åbo Akademi University, 17.12.2010)The currently used forms of cancer therapy are associated with drug resistance and toxicity to healthy tissues. Thus, more efficient methods are needed for cancer-specific induction of growth arrest and programmed cell ... -
Mechanisms of Nascent Transcription in Cell Stress
(Åbo Akademi - Åbo Akademi University, 13.05.2022)Cells are constantly exposed to various types of stress, such as proteotoxic stress, oxidative stress, and hypoxia. Survival under these circumstances requires genome-wide reprogramming of transcription involving both ... -
Membrane lipid frustration : Contribution of ceramide and its effects on lateral segregation
(Åbo Akademi University, 17.06.2021)Ceramides are both sphingolipid precursor molecules and breakdown products with effects on membranes that are of interest both from biophysical and physiological points of view. When present in a membrane, ceramide induces ... -
Membrane properties of structurally modified ceramides : effects on lipid lateral distribution and sphingomyelin-interactions in artificial bilayer membranes
(Åbo Akademi - Åbo Akademi University, 14.03.2014)Ceramides comprise a class of sphingolipids that exist only in small amounts in cellular membranes, but which have been associated with important roles in cellular signaling processes. The influences that ceramides have ... -
Met1-ubiquitination determines inflammatory signalling in Drosophila melanogaster
(Åbo Akademi - Åbo Akademi University, 15.06.2022)The innate immune response is an immediate immune response facilitated by the host to combat pathogen invasion and other harmful stimuli, such as damaged cells and environmental irritants. It is activated when pattern-recognising ... -
Models to study intermediate filament dynamics and functions
(Åbo Akademi - Åbo Akademi University, 08.01.2016)Intermediate filaments are part of the cytoskeleton and nucleoskeleton; they provide cells with structure and have important roles in cell signalling. The IFs are a large protein family with more than 70 members; each ...