Selaus asiasanan mukaan kokoelmassa Åbo Akademi
Viitteet 1-20 / 81
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3D structural modeling of Klebsiella pneumoniae SEFIR domain protein and insights into its putative interaction with IL-17 receptor A
(2022)Salassapidettävä 1.6.2026 asti -
Autoimmunity-associated polymorphisms and their effects on the immunophenotype : Cohort generation and subject immunophenotyping in the Finnish Diabetes Prediction and Prevention study
(2021)Type 1 diabetes (T1D) has a multifactorial etiology wherein both genetic and environmental factors predispose and modulate an individual’s risk of developing the disease. Hereditary factors are perceived to be the fundamental ... -
BET-hämmare för behandling av klarcellig äggstockscancer
(Åbo Akademi, 2019)Klarcellig äggstockscancer (eng. ovarian clear cell carcinoma, OCCC) är en ovanlig cancerform för vilken överlevnadsgraden är låg eftersom behandlingen inte har förbättrats på tiotals år. Sekvenseringsstudier har visat att ... -
Bioimage Analysis for Life Scientists : Tools for Live Cell Imaging
(Åbo Akademi - Åbo Akademi University, 26.04.2024)Live imaging is essential in visualizing biological processes such as normal tissue development, wound healing, and cancer — processes too small for the bare human eye to observe. Optical microscopy has enabled the ... -
Calcium Signaling in Cell Compartments - the Importance of Sphingosine Kinase 1 and ORP5/8
(Åbo Akademi - Åbo Akademi University, 21.06.2023)För att upprätthålla liv använder cellerna i en organism intrikata signaleringsräckor för regleringen av fysiologiska processer inom enskilda celler och mellan olika celler och vävnaderna som utgör en organism. Reglering ... -
Cellular regulation of the Notch signaling pathway by Notch-interacting proteins
(Åbo Akademi University, 25.09.2020)The Notch signaling mechanism is a crucial regulator of stem cells during development and tissue regeneration. Transcriptional activation of Notch target genes requires cleavage of the Notch receptor in response to ligand ... -
Characterization of HSF1 Interactome during Anisomelic Acid Treatment Using TurboID Proximal Labeling
(2023)The heat shock response involves the expression of molecular chaperones that aid in re-folding or degradation of proteins in physiological and pathological conditions that promote accumulation of misfolded proteins. A key ...Embargo 16.6.2024 asti -
Colonocyte Keratins are upregulated in hypoxia and affects nuclear translocation of HIF-1a
(Åbo Akademi, 2019)The cytoskeleton is divided into three types: microtubules, microfilaments and intermediate filaments (IFs). IFs are further divided into 6 different types. First two types of IFs are type I and type II keratins. Keratins ...Embargo until 24.5.2020 -
Comparison of in vitro high content screening methods for drug genotoxicity
(2021)Detection of chemicals that induce damage to the DNA is an important aspect in drug development. The recognition of these chemicals is based on in vitro studies followed by in vivo studies, the latter being both expensive ... -
—Danio rerio— : Extracellular matrix and cancer cell growth in the zebrafish xenograft model
(2023)Cancer is an exponentially growing health concern worldwide. Besides genetic mutations and altered proliferation patterns, the microenvironment, and the cancer cell niche function as an essential regulator of the tumors’ ... -
Deciphering the molecular composition of tricellular junctions
(Åbo Akademi, 2020)Tight Junctions (TJs) are intercellular adhesion complexes that contain an elaborate network of both transmembrane and cytosolic proteins, regulating epithelium integrity. In this thesis, I studied the interactome of a ... -
Developing an in vitro model and quantitation method for bone marrow adiposity research
(2021)Bone marrow adipocytes (BMAds) have long been considered a passive and pathological filler within the bone marrow (BM) microenvironment. Recent studies suggest that BMAds may actively influence bone and energy metabolism. ...Embargo 26.5.2022 asti -
Development of a T Cell Exhaustion Assay for Identification of Novel Immuno-Oncology Targets and In Vitro Drug Screening
(2021)Cancer immunotherapy utilizes the body’s own immune system to treat cancer. The key cell type in immunotherapy is T cells. T cells recognize tumor-associated antigens through their T cell receptors (TCRs) and respond to ...Salassapidettävä 27.5.2025 asti. -
Development of Novel Drugs Targeting Chaperones of Oncogenic K-Ras
(Åbo Akademi - Åbo Akademi University, 12.02.2021)KRAS mutations account globally for about one million deaths per year, but there is as yet no approved drug against KRAS. K-Ras proteins are organized into di-/oligomeric nanoscale signaling complexes, known as nanoclusters ... -
drICE förhindrar bakterieförmedlad inflammation i Drosophila melanogasters tarm
(Åbo Akademi, 2018)Redan vid födseln koloniseras människans tarmkanal av symbiotiska bakterier, även kallade för kommensala bakterier. De kommensala bakteriearterna hjälper att skydda tarmepitelet från patogena mikroorganismer. En minskad ...Embargo 13.12.2021 asti -
dSting reglerar den antivirala NF-ĸB-förmedlade immunresponsen i bananflugan
(2022)Drosophila melanogaster (bananflugan) utgör en utmärkt modellorganism för studier inom immunförsvaret – närmare sagt det ospecifika immunförsvaret, då bananflugan saknar ett specifikt immunförsvar. Bananflugans immunresponser ... -
Effekten av DSS och mesoporösa kiseldioxidnanopartiklar på tarmfloran och inflammationsresponsen i Drosophila melanogaster
(Åbo Akademi, 2019)Drosophila melanogaster är en ofta använd modellorganism för att studera de bakomliggande genetiska och molekylära orsakerna till inflammatoriska tarmsjukdomar – sjukdomar som bl.a. karaktäriseras av en rubbad tarmflora, ...Embargo untill 11.6.2020 -
En ny roll för värmechockfaktor 2 i TGF-β-signalräckan
(Åbo Akademi, 2018)Embargo until 13.12.2023 -
Engineering DoxA activity through the manipulation of associated electron transport partners
(2021)Doxorubicin (DXR) is an anthracycline produced by some strains of the bacterium Streptomyces peucetius subsp. caesius. It is one of the most commonly used drugs in the treatment of several different types of cancer. It is ...Embargo 14/6/2022 asti. -
Epigenetic Markers in T-cell Acute Lymphoblastic Leukemia at Single-Cell Level
(Åbo Akademi, 2019)