Multimodal approach to the evaluation of diffuse neuroinflammation in multiple sclerosis using positron emission tomography and diffusion tensor imaging
Bezukladova, Svetlana (2018)
Bezukladova, Svetlana
Åbo Akademi
2018
Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty.
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi-fe2018091735956
https://urn.fi/URN:NBN:fi-fe2018091735956
Tiivistelmä
Neuroinflammation, neurodegeneration and demyelination of brain, spinal cord and optic nerves are attributed to multiple sclerosis (MS) pathogenesis. Conventional magnetic resonance imaging (MRI) is mainly used for evaluation of inflammatory activity and diffuse atrophy in diagnosis and follow-up in MS. Diffusion tensor imaging (DTI) implementation makes it possible to reveal microstructural alterations in normal appearing white matter tracts, undetectable in conventional MRI. Positron emission tomography (PET) in vivo molecular imaging of activated microglia with translocator protein (TSPO) binding radioligand, provide additional information on the inflammatory activity in normal appearing white matter (NAWM) as well as in the differentiation between the chronic active and inactive MS lesion type. Combination of both imaging modalities will enable a better understanding of MS pathology and can possibly contribute to the prediction of a progressive course of the disease.
The aim of this research was to evaluate structural and molecular brain changes using combined MR and PET in vivo imaging techniques in MS patients compared to healthy controls (HC), with correlational analyses of DTI data to TSPO-PET radioligand binding. The data of 55 MS patients with both RRMS (n = 40) and SPMS (n = 15) disease types and 15 healthy subjects were acquired from previously performed MS imaging studies in Turku PET Centre.
The aim of this research was to evaluate structural and molecular brain changes using combined MR and PET in vivo imaging techniques in MS patients compared to healthy controls (HC), with correlational analyses of DTI data to TSPO-PET radioligand binding. The data of 55 MS patients with both RRMS (n = 40) and SPMS (n = 15) disease types and 15 healthy subjects were acquired from previously performed MS imaging studies in Turku PET Centre.
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