TABLE OF CONTENTS

LIST OF ORIGINAL PUBLICATIONS

ABBREVIATIONS

1. INTRODUCTION

2. REVIEW OF THE LITERATURE

Human memory

• Different memory systems
• Neurobiological correlates of human memory
• Clinical amnesic subtypes

Neurological outcome in various encephalitides

• Herpes virus group
• Arboviruses
• Other viral encephalitides
• Non-viral causes of acute encephalitis

Diagnosis

• Clinical picture
• Confirmatory laboratory investigations
• Neurophysiological recordings
• Neuroradiological imaging

Neuropsychological findings in encephalitis

• Cognitive functioning in Herpes simplex virus 1 encephalitis
• Cognitive functioning in other encephalitides
• Psychiatric symptoms

3. AIMS OF THE STUDY

4. SUBJECTS AND METHODS

Encephalitic subjects

• Diagnosis
• Anti-viral treatment
• EEG recording
• Brain imaging

Control subjects

Study groups

Neuropsychological assessment

Statistical analyses

5. RESULTS

Isolated retrograde amnesia (study I)

Frequency of global amnesia and analysis of anterograde memory disorder in encephalitides (study II)

Quality of memory impairment in Herpes zoster encephalitis (study III)

Follow-up of the cognitive sequelae (study IV)

Transient encephalitic amnesia (study V)

6. DISCUSSION

Issues in diagnostics and in neuropsychological measurement

Amnesia in encephalitides

• Isolated retrograde amnesia
• Permanent global amnesia
• Quality of anterograde amnesia
• Transient encephalitic amnesia

Neuropsychological findings in Herpes zoster encephalitis

Neuropsychological outcome of Herpes simplex virus 1 encephalitis

Recovery of cognitive functions

• Improvement in follow-up
• Frequency of dementia

Implications for the future

7 CONCLUSION

ACKNOWLEDGEMENT

REFERENCES

Author's home page

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